The effects of peppermint oil and eucalyptus oil preparations on neurophysiological, psychological and experimental algesimetric parameters were investigated in 32 healthy subjects in a double-blind, placebo-controlled, randomized cross-over design. Four different test preparations were applied to large areas of the forehead and temples using a small sponge and their effect was evaluated by comparing baseline and treatment measure. The combination of peppermint oil, eucalyptus oil and ethanol increased cognitive performance and had a muscle-relaxing and mentally relaxing effect, but had little influence on pain sensitivity. A significant analgesic effect with a reduction in sensitivity to headache was produced by a combination of peppermint oil and ethanol. The essential plant oil preparations often used in empiric medicine can thus be shown by laboratory tests to exert significant effects on mechanisms associated with the pathophysiology of headache.
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http://dx.doi.org/10.1046/j.1468-2982.1994.014003228.x | DOI Listing |
Chem Biodivers
January 2025
INRGREF: Institut National de Recherche en Genie Rural Eaux et Forets, Forestry, Tunis, Tunis, TUNISIA.
Leaf essential oils (EOs) of seven Eucalyptus species from southern Tunisia (E. gracilis, E. lesouefii, E.
View Article and Find Full Text PDFMolecules
January 2025
Department of Pharmaceutical Botany, Faculty of Pharmacy, Near East University, 99010 Nicosia, Cyprus.
The genus L'Hér., is native to Australia with 61 introduced taxa in Cyprus, including Luehm., which has a wide distribution on the island.
View Article and Find Full Text PDFCurr Pharm Biotechnol
January 2025
Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Background: Benign prostatic hyperplasia is a non-malignant growth of the prostate gland; it's the most common prostatic growth in aging men. 1,8-cineole is a natural compound that is extracted from the essential oil of several aromatic plants including Eucalyptus spp. Recent studies have demonstrated the anti-inflammatory, antioxidant, and anticancer activities of 1,8-cineole.
View Article and Find Full Text PDFInt J Nanomedicine
January 2025
Department of Pharmaceutics, Faculty of Pharmacy, Northern Border University, Arar, Saudi Arabia.
Introduction: Rhein, a natural bioactive lipophilic compound with numerous pharmacological activities, faces limitations in clinical application due to poor aqueous solubility and low bioavailability. Thus, this study aimed to develop a rhein-loaded self-nano emulsifying drug delivery system (RL-SNEDDS) to improve solubility and bioavailability.
Methods: The RL-SNEDDS was prepared by aqueous titration method with eucalyptus oil (oil phase), tween 80 (surfactant), and PEG 400 (co-surfactant) and optimization was performed by 3 factorial design.
Cell Mol Biol (Noisy-le-grand)
January 2025
Laboratory of Cellular Toxicology, Faculty of Science, Department of Biology, Badji Mokhtar University, Annaba, Algeria.
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