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Placental ischemia during pregnancy induces hypertension, cerebral inflammation, and oxidative stress in dams postpartum.
Hypertens Pregnancy
December 2025
Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA.
Background: Preeclampsia (PE) is characterized as de novo hypertension (HTN) with end-organ damage, especially in the brain. PE is hypothesized to be caused by placental ischemia. PE affects ~5-8% of USA pregnancies and increases the risk for HTN and cerebrovascular diseases (CVD) later in life.
View Article and Find Full Text PDFTargeting RNA splicing modulation: new perspectives for anticancer strategy?
J Exp Clin Cancer Res
January 2025
Department of Pharmacology, School of Pharmacy, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province, 110122, P. R. China.
The excision of introns from pre-mRNA is a crucial process in the expression of the majority of genes. Alternative splicing allows a single gene to generate diverse mRNA and protein products. Aberrant RNA splicing is recognized as a molecular characteristic present in almost all types of tumors.
View Article and Find Full Text PDFPrevalence and risk factors of under-five mortality due to severe acute malnutrition in Africa: a systematic review and meta-analysis.
Syst Rev
January 2025
Bill and Joyce Cummings Institute of Global Health, University of Global Health Equity (UGHE), Butaro, Rwanda.
Background: Despite a global drop of under-five mortality by 59% between 1990 and 2019, it remains high in Low- and Middle- income Countries (LMICs)with a preponderance in Sub-Saharan Africa (SSA), Southern and Central Asia. Besides preterm and intrapartum complications, undernutrition contributes 45% of the deaths in these developing regions. In Africa, under-five mortality due to severe acute malnutrition (SAM) has stagnated at 10-40%, higher than WHO targets and the SDGs projections.
View Article and Find Full Text PDFFactors, characteristics and influences of the changes of muscle activation patterns for patients with knee osteoarthritis: a review.
J Orthop Surg Res
January 2025
Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China.
Background: Knee Osteoarthritis (KOA) is a prevalent condition worldwide, significantly diminishing quality of life and productivity. Except for the alignment change, muscle activation patterns (MAP) have garnered increasing attention as another crucial factor contributing to KOA.
Objective: This study explores the factors, characteristics, and effects of MAP changes caused by KOA, providing a neuromuscular-based causal analysis for the rehabilitation treatment of KOA.
Biofilm characterisation of Mycoplasma bovis co-cultured with Trueperella pyogenes.
Vet Res
January 2025
Animal Health Unit, Department of Veterinary Science, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
Mycoplasma pneumonia, caused by Mycoplasma bovis (Mycoplasmopsis bovis; M. bovis), is linked with severe inflammatory reactions in the lungs and can be challenging to treat with antibiotics. Biofilms play a significant role in bacterial persistence and contribute to the development of chronic lesions.
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