The investigations of enzyme activity such as aspartate aminotransferase (AST, KE 2.6.1.1.) and alanine aminotransferase (ALT, KE 2.6.1.2) playing an important role in proteins metabolism were carried out in cell fraction of rat liver, myocardial and skeleton muscle after the influence of ionizing radiation (6 Gy) and the maximum physical loading. It was shown that physical loading furthered the increase of ALT-activity in all cell fractions except liver cytosol. And it was noted a strongly pronounced tendency of AST-activity to lowering, except muscle cell fractions. ALT-activity level in irradiated animals showed phase changes dependent on the term of observation and the kind of investigated tissues. The primary lowering of AST-activity in cell fractions of the investigated tissues is a conformity to natural laws of the gamma-irradiation influence on AST in most cases. It was shown that the physical tiredness made worse penetrated radiation action on the investigated enzymes.
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