Authors review principles and occurrence of sex-impairment correlated with neoplasia and related treatments. Main altering effects appear due to chemotherapy and hormone manipulation, but even surgery and radiotherapy, as well as supportive care are able to induce sex dysfunctions, either physically or psychologically. A specific grading scale (with increasing intensity from 0 to 4) is proposed, following general WHO suggestions in medical oncology, with the aim of recording and prospectively evaluating clinical data in a reproducible fashion.
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