The changes in the frequency content of electrograms of the optic cortical area and deep structures of the brain (putamen, dorsal hippocampus, medial part of the hypothalamus) were studied during intraventricular introduction of various doses of GABA-receptor agonists (GABA, muscimol, baclofen) and antagonist (bicuculline). The latter was found to affect the overall electrical activity slightly regardless of the dose. When muscimol and baclofen were injected, the greatest EG effect was observed at 1.10(-9) mole. A dose-dependent reversion of EG effects was revealed for GABA and muscimol; at the alpha-range 1.10(-6) mole, of GABA was found to weaken rhythmic activity, while 1.10(-8) mole of muscimol increased and 1.10(-9) mole decreased the power of alpha-rhythm. The correlation analysis of EG changes suggests that there is one interdependent mechanism or more for formation of EG of the range studied which operate by the starting mechanism.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Multifunctional Artificial Electric Synapse of MoSe-Based Memristor toward Neuromorphic Application.
J Phys Chem Lett
January 2025
Key Laboratory of Atomic and Molecular Physics and Functional Materials of Gansu Province, College of Physics and Electronic Engineering, Northwest Normal University, Lanzhou 730070, China.
Research on memristive devices to seamlessly integrate and replicate the dynamic behaviors of biological synapses will illuminate the mechanisms underlying parallel processing and information storage in the human brain, thereby affording novel insights for the advancement of artificial intelligence. Here, an artificial electric synapse is demonstrated on a one-step Mo-selenized MoSe memristor, having not only long-term stable resistive switching characteristics (reset 0.51 ± 0.
View Article and Find Full Text PDFROCK Inhibitor Enhances Resilience Against Metabolic Stress Through Increasing Bioenergetic Capacity in Corneal Endothelial Cells.
Invest Ophthalmol Vis Sci
January 2025
Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
Purpose: To investigate the effect of Rho-associated protein kinase (ROCK) inhibitor Y27632 on bioenergetic capacity and resilience of corneal endothelial cells (CECs) under metabolic stress.
Methods: Bovine CECs (BCECs) were treated with Y27632 and subjected to bioenergetic profiling using the Seahorse XFp Analyzer. The effects on adenosine triphosphate (ATP) production through oxidative phosphorylation and glycolysis were measured.
Evaluation of the effect of the water-energy nexus on the performance of the water-energy supply system.
Environ Sci Pollut Res Int
January 2025
Department of Civil Engineering, University of Qom, Qom, Iran.
In this study, the water-energy nexus is investigated throughout coupling the Water Evaluation and Planning (WEAP) and Low Emission Analysis Platform (LEAP) models under the climate change effects in the Marun basin, Iran. For this purpose, first, the climate change effects on water resources and consumption nodes are calculated under representative concentration pathway (RCP) scenarios from the fifth report of the International Panel on Climate Change (IPCC). Artificial neural network (ANN) is used to model river inflow and Cropwat model is used for agricultural water demand in future time (2015-2040).
View Article and Find Full Text PDFAn In Vivo Biostability Evaluation of ALD and Parylene-ALD Multilayers as Micro-Packaging Solutions for Small Single-Chip Implants.
Small
January 2025
Department of Microelectronics, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Delft, 2628 CN, The Netherlands.
Miniaturization of next-generation active neural implants requires novel micro-packaging solutions that can maintain their long-term coating performance in the body. This work presents two thin-film coatings and evaluates their biostability and in vivo performance over a 7-month animal study. To evaluate the coatings on representative surfaces, two silicon microchips with different surface microtopography are used.
View Article and Find Full Text PDFElectrosynthesis of Ru (II)-Polypyridyl Oligomeric Films on ITO Electrode for Two Terminal Non-Volatile Memory Devices and Neuromorphic Computing.
Small Methods
January 2025
Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, 208016, India.
Molecular electronics exhibiting resistive-switching memory features hold great promise for the next generation of digital technology. In this work, electrosynthesis of ruthenium polypyridyl nanoscale oligomeric films is demonstrated on an indium tin oxide (ITO) electrode followed by an ITO top contact deposition yielding large-scale (junction area = 0.7 × 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!