The effects of X-ray contrast agents on human blood rheology were investigated. The main cause of rheological effects of X-ray contrast media is their action on the structure and function of erythrocytes. There was a relationship between the physicochemical properties and the mechanism of action. The major active factor is the high osmolality of X-ray contrast media solutions. Lipid solubility, specific features of molecular structures and the composition of a dosage form played a definite role.
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