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| http://dx.doi.org/10.1136/bmj.309.6960.1020d | DOI Listing |
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Homozygous Delta-Beta Thalassaemia With Alpha Thalassaemia and Erythrocytosis- a Rare Case Report.
Br J Biomed Sci
December 2024
Department of Hematology, Sandwell and West, Birmingham Hospitals National Health Service Trust, West Bromwich, United Kingdom.
In this report, we describe a case of homozygous delta-beta (δβ) thalassaemia, a rare genetic disorder characterized by severe deficiency in delta (δ) and beta (β)-globin chain production, leading to ineffective erythropoiesis and chronic haemolytic anaemia. The patient, a 26-year-old female with δβ-thalassaemia, experienced a miscarriage. High-performance liquid chromatography revealed 89.
View Article and Find Full Text PDF[Fetal death: Expert consensus from the College of French Gynecologists and Obstetricians].
Gynecol Obstet Fertil Senol
October 2024
Service de gynécologie-obstétrique, CHU Charles-Nicolle, Rouen, France.
Fetal death is defined as the spontaneous cessation of cardiac activity after fourteen weeks of amenorrhea. In France, the prevalence of fetal death after 22 weeks is between 3.2 and 4.
View Article and Find Full Text PDFFetomaternal Hemorrhage and Choriocarcinoma: A Case Report.
Adv Neonatal Care
October 2024
Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia.
Background: This case describes chronic anemia of a late preterm infant secondary to maternal-fetal hemorrhage and subsequent findings of maternal choriocarcinoma.
Clinical Findings: This infant was born at 35 6/7 weeks gestational age via cesarean section for non-reassuring fetal heart tones. The mother presented with decreased fetal movement and the biophysical profile was 4/8.
Routine maternal ABO/Rhesus D blood typing can alert of massive foetomaternal haemorrhage.
Vox Sang
October 2024
Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Background And Objectives: Spontaneous massive foetomaternal haemorrhage (SM-FMH) is a rare yet critical condition that poses substantial risk to foetal health and survival. Existing data indicate that many cases may be undiagnosed. The current study aimed to investigate and validate the utility of identifying mixed field red blood cell (RBC) agglutination during maternal blood typing as a diagnostic aid for SM-FMH.
View Article and Find Full Text PDFHPLC and flow cytometry combined approach for HbF analysis in fetomaternal haemorrhage evaluation.
Pract Lab Med
May 2024
Flow Cytometry Diagnostic Centre and Immunotherapy (CDCI), AOU Careggi, Largo Brambilla, 3, 50134, Florence, Italy.
Introduction: Recently, a flow cytometric (FC) based test has been developed for detection of circulating fetal cells to replace the less accurate and reproducible Kleihauer-Betke test.FC test is easier to perform, it can distinguish the origin of fetal cells, but it is expensive and available in highly specialized laboratories. We evaluated the introduction of high-performance liquid chromatography (HPLC) approach as initial screening to identify patients who need an additional FC test to better discriminate the nature of haemoglobin-F (HbF) positive cells.
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