D-Glucose, but not L-glucose or 3-O-methyl-D-glucose, stimulates 45Ca2+ uptake by both lanthanum-displaceable and lanthanum-nondisplaceable pools in pancreatic islets. The nondisplaceable pool probably represents secretory granules, while the displaceable pool may be located in the beta-cell membrane. Kinetic studies with isotopically labeled islets suggest that only the displaceable pool participates in the short-term coupling of the glucose stimulus with secretion.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1126/science.795030 | DOI Listing |
Publication Analysis
Top Keywords
pancreatic islets
8
displaceable pool
8
calcium secretion
4
secretion distinction
4
distinction pools
4
pools glucose-sensitive
4
glucose-sensitive calcium
4
calcium pancreatic
4
islets d-glucose
4
d-glucose l-glucose
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!