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Single nucleotide polymorphism-based visual identification of using the loop-mediated isothermal amplification technique.
Front Plant Sci
January 2025
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.
Introduction: (Hook.f. & Thomson) H.
View Article and Find Full Text PDFChiral Oxazoline-Triazole-Benzothiazole Molecular Triads: Photoactive Sensors for Enantioselective Carbohydrate Recognition in Solution.
JACS Au
January 2025
Instituto de Química, Universidade Federal do Rio Grande do Sul-UFRGS, Av. Bento Gonçalves 9500, 91501-970 Porto Alegre, Rio Grande do Sul, Brazil.
Understanding the mechanism of drug action in biological systems is facilitated by the interactions between small molecules and target chiral biomolecules. In this context, focusing on the enantiomeric recognition of carbohydrates in solution through steady-state fluorescence emission spectroscopy is noteworthy. To this end, we have developed a third generation of chiral optical sensors for carbohydrates, distinct from all of those previously presented, which interact with carbohydrates to form non-covalent probe-analyte interactions.
View Article and Find Full Text PDFExpedient discovery of fluorogenic amino acid-based probes one-pot palladium-catalysed arylation of tyrosine.
Chem Sci
January 2025
School of Chemistry, University of Glasgow Joseph Black Building, University Avenue Glasgow G12 8QQ UK
To overcome the limitations of using large extrinsic chromophores for biological imaging, fluorescent unnatural α-amino acids have been widely adopted as intrinsic peptidic probes. Although various classes have been successfully utilised for imaging applications, novel amino acid probes readily prepared through operationally simple synthetic methodology are still required. Here, we report a new approach for the synthesis of unnatural α-amino acids a one-pot process involving activation and palladium-catalysed arylation of tyrosine.
View Article and Find Full Text PDFA perylene-based fluorescent probe for highly efficient SDS detection.
Anal Methods
January 2025
Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA.
Sodium dodecyl sulfate (SDS) is widely used in numerous household products and pharmaceuticals due to its excellent water solubility, emulsification, foaming, and dispersing properties. However, the extensive use of SDS has made it a significant environmental pollutant, posing a great threat to aquatic ecosystems. Therefore, developing a rapid, efficient, and sensitive probe for detecting SDS in aqueous environments is crucial.
View Article and Find Full Text PDFCarbon dots derived from organic drug molecules with improved therapeutic effects and new functions.
Nanoscale
January 2025
Department of Chemistry and Shanghai Key Laboratory of Molecular and Catalysis and Innovative Materials, Fudan University, Shanghai 200438, P. R. China.
Carbon dots (CDs) are new types of fluorescent nanomaterials with particle diameters of 1∼10 nm and have excellent photoluminescence (PL) properties, good biocompatibility, simple preparation methods and numerous raw materials; consequently, they are promising in the biomedical field. In recent years, to overcome drug resistance and toxic side effects of traditional organic drugs, the synthesis of CDs from drug molecules has become an effective strategy, which produces CDs with the same therapeutic effects as the raw drugs and even possessing new properties. At present, many CDs derived from organic drugs have been developed, which can be classified according to their sources such as antibiotics, anti-inflammatory drugs, and guanidine drugs.
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