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2025 Expert Consensus Recommendations for the Diagnostic Requirements in Routine Practices of Transthoracic Echocardiography.
Acta Cardiol Sin
January 2025
Division of Cardiology, Department of Internal Medicine, China Medical University Hospital and College of Medicine, China Medical University, Taichung.
Transthoracic echocardiography plays a crucial role in clinical diagnosis and is increasingly being used around the world. Comprehensive echocardiographic examinations require accurate measurements and the operators to have excellent technical skills. Despite the availability of several published echocardiographic guidelines, the absence of recommended operational manuals in daily practice has resulted in significant variation in the content of echocardiography reports across different medical institutions.
View Article and Find Full Text PDFClinical Evaluation of an Electronic Guidance System for Optimizing the Ultrasound Screening for Developmental Hip Dysplasia in Newborns.
J Clin Med
December 2024
Department of Orthopedics and Trauma Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Graf ultrasound screening is considered an established method for early detection of developmental dysplasia of the hip (DDH). Although characterized by a high degree of standardization to allow for good reproducibility of results, examination-related factors may still affect sonographic measurements. The relative tilt angle between the hip and the probe is a potential pitfall as it significantly influences sonographic measurements and consequently classification of DDH according to Graf.
View Article and Find Full Text PDFFrequently asked questions on surrogate endpoints in oncology-opportunities, pitfalls, and the way forward.
EClinicalMedicine
October 2024
Department of Oncology, Queen's University, Kingston, Canada.
Patients with cancer expect prolonged life (overall survival, OS) or better life (quality of life, QOL) from cancer treatments. However, majority of new cancer drugs are now being approved not based on improved OS or QOL, but based on surrogate endpoints such as tumor shrinkage or delayed tumor progression. These surrogate endpoints, including their validity as a proxy for overall survival, differ based on disease settings and lines of treatment but in general, most surrogate measures have weak correlation with outcomes that matter to patients.
View Article and Find Full Text PDFPitfalls of the E-Ref Procedure: Tie Values and the Proportion of the Abnormal Data.
Muscle Nerve
January 2025
Department of Neurology, Teikyo University School of Medicine, Tokyo, Japan.
Introduction: Extrapolated reference values (E-Ref) procedure is a new method for determining the cutoff value without collecting the control data. We tried to apply this method to determine the cutoff value for the distal motor latency of the median nerve (median DML). During this process, we found two pitfalls of the E-Ref method.
View Article and Find Full Text PDFPredicting Climate Mitigation Through Carbon Burial in Blue Carbon Ecosystems-Challenges and Pitfalls.
Glob Chang Biol
January 2025
Department of Biology, University of Southern Denmark, Odense, Denmark.
The concept of "blue carbon" is, in this study, critically evaluated with respect to its definitions, measuring approaches, and time scales. Blue carbon deposited in ocean sediments can only counteract anthropogenic greenhouse gas (GHG) emissions if stored on a long-term basis. The focus here is on the coastal blue carbon ecosystems (BCEs), mangrove forests, saltmarshes, and seagrass meadows due to their high primary production and large carbon stocks.
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