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SIRT5 desuccinylating IDH2 to alleviate oxidative stress in bovine mammary epithelial cells induced by ammonia.
Int J Biol Macromol
January 2025
Key Laboratory of Animal Biochemistry and Nutrition, Ministry of Agriculture, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, Henan, China; Key Laboratory of Veterinary Biotechnology of Henan Province, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, Henan, China. Electronic address:
Ammonia can cause cells to produce a large amount of reactive oxygen species (ROS), leading to the oxidative stress of cells. As the main intracellular reductant, nicotinamide adenine dinucleotide phosphate (NADPH) plays a crucial role in maintaining reduced glutathione (GSH), helping to remove ROS and protect cells from oxidative damage. Our study demonstrated that SIRT5 desuccinylated isocitrate dehydrogenase 2 (IDH2) to enhance its activity, resulting in increased NADPH production.
View Article and Find Full Text PDFNicotinamide adenine dinucleotide (NAD(H)) and its metabolites function as crucial regulators of physiological processes, allowing cells to adapt to environmental changes such as nutritional deficiencies, genotoxic factors, disruptions in circadian rhythms, infections, inflammation, and exogenous substances. Here, we investigated whether elevated NAD(H) levels in oocytes enhance their quality and improve developmental competence following in vitro fertilization (IVF). Bovine cumulus-oocyte complexes (COCs) were matured in a culture medium supplemented with 0-100 μM nicotinamide mononucleotide (NMN), a precursor of NAD(H).
View Article and Find Full Text PDFWhole-genome methylation reveals tissue-specific differences in non-CG methylation in bovine.
Zool Res
November 2024
State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestocks, Inner Mongolia University, Hohhot, Inner Mongolia 010070, China. E-mail:
Article Synopsis
- DNA methylation at non-CG dinucleotides (mCH) is prevalent in certain cell types like pluripotent and neural cells, yet its roles in species outside of humans and mice are not well understood.
- This study examined mCH distribution in various bovine tissues, discovering higher levels in embryonic stem cells and specific organs, while also highlighting differences between somatic cells and stem cells.
- Findings indicate that mCH is concentrated in certain functional regions rather than being randomly distributed, suggesting it may play significant roles in development and disease, contributing valuable insights into epigenetics in bovines and beyond.
Molecular identification and genetic variability of equine and bovine ocular setariasis in india: molecular profiling by mitochondrial genes.
Mol Biol Rep
August 2024
Division of Parasitology, ICAR- Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India.
Background: Ocular setariasis is an ectopic infection caused by a parasite under the genus Setaria. Adult worms belong to the Setariidae family and typically reside in the peritoneal cavity of ungulates. However, immature forms of these species may aberrantly migrate to the eyes of cattle, buffalo, goats, horses and several other hosts, leading to corneal opacity and blindness.
View Article and Find Full Text PDFPolymorphism analysis of tri- and tetranucleotide repeat microsatellite markers in Hanwoo cattle.
J Anim Sci Technol
July 2024
Hanwoo Research Institute, National Institute of Animal Science, Pyeongchang 25340, Korea.
The Hanwoo traceability system currently utilizes 11 dinucleotide repeat microsatellite (MS) markers. However, dinucleotide repeat markers are known to have a high incidence of polymerase chain reaction (PCR) artifacts, such as stutter bands, which can complicate the accurate reading of alleles. In this study, we examined the polymorphisms of the 11 dinucleotide repeat MS markers currently employed in traceability systems.
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