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A non-inferiority randomized controlled study of Perampanel versus Oxcarbazepine monotherapy for post-stroke epilepsy.
Seizure
January 2025
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, PR China; Institute of Epilepsy, Shandong University, Jinan, Shandong, PR China. Electronic address:
Background: Post-stroke epilepsy (PSE) poses a significant challenge despite advances in stroke treatment. This study compares the efficacy of the novel anti-seizure medication (ASM) Perampanel with the classical ASM Oxcarbazepine in treating PSE.
Methods: This prospective randomized controlled trial recruited PSE patients from September 2022 to January 2024 across multiple hospitals.
Mechanism of hyperbaric oxygen therapy downregulating H-type angiogenesis in subchondral bone of knee osteoarthritis through the PHD2/HIF-1α pathway.
J Orthop Surg Res
January 2025
Department of Rehabilitation Medicine, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, 225001, China.
Objective: To explore the mechanism of hyperbaric oxygen therapy in inhibiting subchondral bone angiogenesis and delaying the progression of osteoarthritis through the PHD2/HIF-1α signaling pathway.
Methods: Mice were randomly divided into three groups (control group, osteoarthritis group, and hyperbaric oxygen treatment group). The effect of hyperbaric oxygen therapy on osteoarthritis was evaluated using Micro-CT, Safranin O-Fast Green staining, and detection of osteoarthritis inflammation markers (MMP-13, ADAMTS-5, Col2a1, and Aggrecan).
Adjunctive Hyperbaric Oxygen Therapy for Patients with Chronic Refractory Osteomyelitis: A Report of Treatment Outcomes and Risk Factors for Treatment Failure.
Adv Skin Wound Care
January 2025
At the University of South Carolina, Columbia, South Carolina, USA, J. Benjamin Jackson III, MD, MBA, is Professor of Orthopaedic Surgery and Director of Orthopaedic Research, Department of Orthopaedics; and Yianni Bakaes, BS, and Ben Jacques, BS, are Medical Students, School of Medicine. Chase Gauthier, MD, is Research Fellow, Prisma Health Department of Orthopedics, Columbia, South Carolina. Also at the University of South Carolina, William L. Mills Jr, MD, and Kenny Nguyen, MD, are Medical Residents, School of Medicine; Tyler Gonzalez, MD, MBA, is Assistant Professor of Orthopaedic Surgery, Department of Orthopaedics; and David L. Cone, MD, is Clinical Associate Professor of Family and Preventative Medicine, School of Medicine. The authors have disclosed no financial relationships related to this article. Submitted September 6, 2023; accepted in revised form January 16, 2024.
Objective: To evaluate the effect of hyperbaric oxygen (HBO) therapy on the outcomes of patients with chronic refractory osteomyelitis (CRO) when combined with modern antibiotics with modern delivery methods and/or surgical treatments.
Methods: The authors conducted a retrospective review on 58 patients with CRO from a single institution who underwent HBO therapy along with standard treatment between January 2009 and December 2019. To investigate associations with binary outcomes of interest, they estimated logistic regression models.
Comparison of the Effectiveness and Safety of Segmental Thoracic Spinal Anesthesia Using Isobaric Levobupivacaine 0.5% Versus Hyperbaric Levobupivacaine 0.5% in Performing Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Trial.
Cureus
December 2024
Community Medicine, Autonomous State Medical College, Auraiya, IND.
Introduction: Laparoscopic cholecystectomy has evolved into a daycare procedure thanks to advancements in both surgical and anesthetic techniques. Regional anesthesia, specifically segmental thoracic spinal anesthesia (TSA), offers distinct benefits over general anesthesia, such as enhanced hemodynamic stability and quicker recovery, especially in high-risk patients. This study aims to compare the sensory and motor block characteristics, hemodynamic stability, and incidence of adverse effects between isobaric and hyperbaric 0.
View Article and Find Full Text PDFOxy-inflammation in hyperbaric oxygen therapy applications.
Eur J Transl Myol
January 2025
Institute of Clinical Physiology, National Research Council (IFC-CNR), Milan.
Hyperbaric oxygen therapy (HBOT) is a non-invasive method of O2 delivery that induces systemic hyperoxia. Hyperbaric chamber consists of a pressure vessel and a compressed breathing gas supply, which can regulate internal pressure. The chamber delivers 100% O2 to patients according to predetermined protocols and is monitored by trained personnel.
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