A quantitative karyological analysis of immature male sex cell (IMSC) composition in ejaculate of males with normal spermogram (a relative standard), oligo-, astheno-, terato- or azoospermia has been made. The specimens were obtained from 100 patients. Because of IMSC absence, a part of the 150 specimens lacked informative value. The proportion of IMSC from ejaculate of fertile patients with normospermia was less than 4%. The cells were mainly spermatids, 26% of which remained unseparated in meiotic division. In oligozoospermia the number of ejaculate IMSC increased (up to 26.4%) as well as that of spermatocytes at the stage of meiotic pachytene and diplotene. The same trend persisted in asthenozoospermic males. In azoospermia the percent of IMSC averaged 52.4% varying greatly from individual to individual. Characteristic for this condition was also increased number of unseparated spermatids. The advantages and prospects of the method are discussed.
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