Prevalence of trypanosomosis, gastrointestinal strongyles and level of strongyle egg outputs were studied in relation to husbandry practices in the draught donkey population in The Gambia. Feeding regime, number of working hours per day and overnight penning practices of donkeys affected significantly (P < 0.05) the level of gastrointestinal strongyle egg output, but not (P > 0.05) trypanosomosis prevalence. Dual trypanosome and gastrointestinal strongyle infection significantly reduced the PCV (P < 0.001). Animals positive for gastrointestinal strongyles alone did not show a significantly (P > 0.05) lower PCV than those found negative. Husbandry practices to improve the situation are recommended.
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PLoS Negl Trop Dis
November 2024
Department of Parasitology, Biochemical and Molecular Parasitology Group CTS-183, and Institute of Biotechnology, University of Granada., Granada, Spain.
Background: Chagas disease, once restricted mainly to the Americas, Chagas disease has become a global health problem due to migration from endemic to non-endemic areas. In non-endemic regions, transmission is limited to vertical transmission from infected mothers to newborns or through blood and organ donations. A major challenge in the management of the disease lies in the diagnosis of chronic cases, as blood-borne parasites are often absent and antibodies persist for life, complicating the evaluation of treatment.
View Article and Find Full Text PDFFood Funct
October 2024
Department of Pathogen Biology and Microecology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
We established a model of cyclophosphamide (CTX)-induced immunosuppressed mice and RAW264.7 cells to assess the effectiveness of BCG44 and its supernatant in enhancing immune function and modulating the gut microbiota. BCG44 and its supernatant restored Th17/Treg balance and alleviated gut inflammation by elevating the expression of interleukin-10 (IL-10) and decreasing IL-6 and toll-like receptor 4 (TLR4).
View Article and Find Full Text PDFParasit Vectors
September 2024
Laboratory of Vector-Pathogen Biology, Proteomic Platform, Department of Molecular Biology, Université Libre de Bruxelles, 6041, Gosselies, Belgium.
Background: Trypanosoma cruzi is transmitted to humans by hematophagous bugs belonging to the Triatominae subfamily. Its intra-vectorial cycle is complex and occurs exclusively in the insect's midgut. Dissecting the elements involved in the cross-talk between the parasite and its vector within the digestive tract should provide novel targets for interrupting the parasitic life cycle and affecting vectorial competence.
View Article and Find Full Text PDFExp Parasitol
October 2024
Postgraduate Program in Health Sciences, Health Sciences Center, State University of Maringá, Maringá, 87.020.900, Brazil; Postgraduate Program in Biological Sciences, Biological Sciences Center, State University of Maringá, Maringá, 87.020.900, Brazil; Department of Basic Health Sciences, Health Sciences Center, State University of Maringá, Maringá, 87.020.900, Brazil. Electronic address:
In Brazil, where Chagas disease is endemic, the most frequent form of transmission of the parasite is the oral route, associated with greater severity and worse response to benznidazole (BZ), the drug used in its treatment. This study aimed to evaluate the impact of gastrointestinal infection (GI) and BZ treatment on the parasitological and histopathological parameters in mice inoculated with a strain of T. cruzi II.
View Article and Find Full Text PDFParasite Immunol
July 2024
Laboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Cascavel, Brazil.
Chagas disease is a parasitic disease caused by the protozoan Trypanosoma cruzi with an acute, detectable blood parasites phase and a chronic phase, in which the parasitemia is not observable, but cardiac and gastrointestinal consequences are possible. Mice are the principal host used in experimental Chagas disease but reproduce the human infection depending on the animal and parasite strain, besides dose and route of administration. Lipidic mediators are tremendously involved in the pathogenesis of T.
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