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Role of transforming growth factor-beta1 in cyclosporine-induced epithelial-to-mesenchymal transition in gingival epithelium.
J Periodontol
January 2015
Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan, ROC.
Background: It has been proposed that cyclosporin A (CsA) may induce epithelial-to-mesenchymal transition (EMT) in gingiva. The aims of the present study are to confirm the notion that EMT occurs in human gingival epithelial (hGE) cells after CsA treatment and to investigate the role of transforming growth factor beta1 (TGF-β1) on this CsA-induced EMT.
Methods: The effects of CsA, with and without TGF-β1 inhibitor, on the morphologic changes of primary culture of hGE cells were examined in vitro.
New insights on the anti-inflammatory effect of some Egyptian plants against renal dysfunction induced by cyclosporine.
Eur Rev Med Pharmacol Sci
April 2012
Hormones Department, National Research Center, Dokki, Egypt.
Objective: This study was undertaken to investigate the anti-inflammatory role of fennel, carob, doum and mixture of them in improving the renal dysfunction induced in rats by the cyclosporine.
Design: Sixty female albino rats were divided into six groups: healthy control rats, cyclosporine injected rats (positive control), other groups were injected by cyclosporine for 7 days and then diet was supplemented with either fennel, doum, carob or mixture of them. After 45 days of supplementation, rats were scarified.
c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes.
J Transplant
November 2011
Unité INSERM U775, Centre Universitaire des Saints-Pères, Université Paris Descartes, 75006 Paris, France.
Tubular epithelial cells play a central role in the pathogenesis of chronic nephropathies. Previous toxicogenomic studies have demonstrated that cyclosporine- (CsA-) induced epithelial phenotypic changes (EPCs) are reminiscent of an incomplete epithelial to mesenchymal transition (EMT) in a TGF-β-independent manner. Furthermore, we identified endoplasmic reticulum (ER) stress as a potential mechanism that may participate in the modulation of tubular cell plasticity during CsA exposure.
View Article and Find Full Text PDFRed wine polyphenols prevent cyclosporine-induced nephrotoxicity at the level of the intrinsic apoptotic pathway.
Physiol Res
December 2009
Department of Biomedical Sciences and Biotechnology, Division of Human Anatomy, University of Brescia, Brescia, Italy.
Flavonoids, polyphenol derivatives of plant origin, possess a broad range of pharmacological properties. A number of studies have found both pro/anti-apoptotic effects for many of these compounds. For these reasons we investigated whether Provinols flavonoids obtained from red wine, have anti-apoptotic properties.
View Article and Find Full Text PDFOral L-arginine protects against cyclosporine-induced hepatotoxicity in rats.
Exp Toxicol Pathol
August 2008
Department of Histology and Embryology, Faculty of Medicine, Inonu University, 44128 Malatya, Turkey.
Cyclosporine A (CyA) leads to liver injury, probably by causing the production of free radicals and resulting in nitric oxide (NO) deficiency. We evaluated CyA-mediated liver damage histopathologically to determine the possible beneficial effects of L-arginine (L-Arg). In this study, 7 groups of Sprague-Dawley rats; (1) Control group; (2) 0.
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