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PSTPIP1-Associated Myeloid-Related Proteinemia Inflammatory (PAMI) Syndrome: A Systematic Review.
Genes (Basel)
August 2023
Pediatric Immuno-Rheumatology of Western Switzerland, Department Women-Mother-Child, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
PSTPIP1 (proline-serine-threonine phosphatase-interactive protein 1)-associated myeloid-related proteinemia inflammatory (PAMI) syndrome, previously known as Hyperzincemia/Hypercalprotectinemia (Hz/Hc) syndrome, is a recently described, rare auto-inflammatory disorder caused by specific deleterious variants in the gene (p.E250K and p.E257K).
View Article and Find Full Text PDFEltrombopag Preserves the Clonogenic Potential of Hematopoietic Stem Cells During Treatment With Antithymocyte Globulin in Patients With Aplastic Anemia.
Hemasphere
June 2023
Department of Hematology, Oncology, Hemostaseology, Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Germany.
Aplastic anemia (AA) is frequently caused by a T-cell mediated autoimmune depletion of the hematopoietic stem and progenitor cell (HSPC) compartment. Immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine represents the first-line treatment of AA. One side effect of ATG therapy is the release of proinflammatory cytokines such as interferon-gamma (IFN-γ), which is considered a major factor in the pathogenic autoimmune depletion of HSPC.
View Article and Find Full Text PDFRelationship of vitamin D level with insulin dosage required based on insulin therapy protocol.
Eur J Transl Myol
February 2023
Clinical Nutrition Department, Hazrat-e Rasool Hospital, School of Medicine, Iran University of Medical Sciences, Tehran.
An Expression of Concern has been published | View Update to April 27th, 2023: The Publisher is glad to inform the readers that the issue discussed in the Expression of Concern has been favorably resolved and we have no longer cause of concern regarding this paper. The deficiency of vitamin D (VD) amongst Iranian people is high and also is related on hyperglycemia. This study aims to evaluate the association of VD levels with the required dose of insulin prescribed based on an insulin therapy protocol in critical condition patients admitted to intensive care unit (ICU), in an investigation based in Iran.
View Article and Find Full Text PDFThe Effect of Anti-Inflammatory Topical Ophthalmic Treatments on In Vitro Corneal Epithelial Cells.
Transl Vis Sci Technol
September 2022
Viterbi Family Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA.
Purpose: To compare the effect of three commonly prescribed anti-inflammatory eye drops on corneal epithelial cells in vitro.
Methods: Three different lines of human corneal epithelial cells were tested: primary cells cultured from donor tissue, commercially available primary cells, and immortalized cells. Cells were seeded on 96-well plates and treated with the following eye drops: cyclosporine 0.
Current state of clinical trials regarding lung transplant rejection.
Transpl Immunol
October 2022
Faculty of Medicine, Lebanese University, Beirut, Lebanon; Lebanese American University, School of Medicine, Lebanon; iNSPECT-LB (Intitut National de Santé Publique, Epidémiologie Clinique et Toxicologie-Liban), Beirut, Lebanon; School of Medicine, University of Nicosia, Cyprus.
Background: Over the last several decades, the field of lung transplantation has made significant advances. Despite these advancements, morbidity and mortality rates are still high when compared to other solid organ transplants. Clinical trials have a significant role bringing new medications with better effects than their predecessors.
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