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Spatio-temporal variability of mesozooplankton distribution along the Canary Current Large Marine Ecosystem: a regional perspective.
J Plankton Res
January 2025
Institute of Marine Research (IMR), PO Box 1870, Nordnes, Bergen NO-5817, Norway.
The Canary Current Large Marine Ecosystem (CCLME), extending from Cape Spartel in Morocco to Guinea-Bissau, supports high primary and fisheries productivity driven by permanent or seasonal upwelling activity. During the current study, mesozooplankton and hydrographic sampling were conducted across the CCLME in the spring/summer of 2017 and the autumn/winter of 2019. The total mesozooplankton abundance and dry weight were found to be higher in 2017, partly due to the summer reproduction cycle of diplostracans.
View Article and Find Full Text PDFAn extracellular vesicle based hypothesis for the genesis of the polycystic kidney diseases.
Extracell Vesicle
December 2024
The Jared Grantham Kidney Institute at the University of Kansas Medical Center, Department of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Autosomal dominant polycystic kidney (ADPKD) disease is the commonest genetic cause of kidney failure (affecting 1:800 individuals) and is due to heterozygous germline mutations in either of two genes, and . Homozygous germline mutations in are responsible for autosomal recessive polycystic kidney (ARPKD) disease a rare (1:20,000) but severe neonatal disease. The products of these three genes, (polycystin-1 (PC1 4302(3)aa)), (polycystin-2 (PC2 968aa)) and (fibrocystin (4074aa)) are all present on extracellular vesicles (EVs) termed, PKD-exosome-like vesicles (PKD-ELVs).
View Article and Find Full Text PDFMapping photoisomerization dynamics on a three-state model potential energy surface in bacteriorhodopsin using femtosecond stimulated Raman spectroscopy.
Chem Sci
January 2025
School of Physical Science and Technology, ShanghaiTech University Shanghai 201210 China
The process of proton translocation in , triggered by light, is powered by the photoisomerization of all--retinal in bacteriorhodopsin (bR). The primary events in bR involving rapid structural changes upon light absorption occur within subpicoseconds to picoseconds. While the three-state model has received extensive support in describing the primary events between the H and K states, precise characterization of each excited state in the three-state model during photoisomerization remains elusive.
View Article and Find Full Text PDFAdvanced bioanalytical techniques for pharmacokinetic studies of nanocarrier drug delivery systems.
J Pharm Anal
January 2025
Research Center for Drug Metabolism, School of Life Sciences, Jilin University, Changchun, 130012, China.
Significant investment in nanocarrier drug delivery systems (Nano-DDSs) has yielded only a limited number of successfully marketed nanomedicines, highlighting a low rate of clinical translation. A primary contributing factor is the lack of foundational understanding of processes. Comprehensive knowledge of the pharmacokinetics of Nano-DDSs is essential for developing more efficacious nanomedicines and accurately evaluating their safety and associated risks.
View Article and Find Full Text PDFEffects of titanium oxide nanoparticles on growth, biochemical composition, and photosystem mechanism of marine microalgae COR-A3.
Nanotoxicology
January 2025
Department of Biotechnology, Sathyabama Institute of Science and technology, Chennai, Tamil Nadu, India.
The widespread utilization of titanium oxide nanoparticles (TiONPs) in various industrial applications has raised concerns about their potential ecological risks in marine environment. Assessing the toxicity of TiONPs on primary producers is essential to understand their impact on marine ecosystem. This study investigates the acute toxicity effect of TiONPs on COR-A3 cells, focusing on structural and physiological changes that can compromise algal viability and ecological function.
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