Radiotherapy treatment planning needs optimum definition of the target volume in its relative position to normal tissue. The motion of the kidneys during respiration has not been well quantified. They move in a tilted coronal and sagittal plane. Using fast MRI while patients held their breath we quantified the movements of the kidneys. Fourteen patients volunteered for the study. Nine MRI images of the kidneys for one volunteer were done: three in the axial plane (all in deep inspiration) and six in the coronal plane (three in deep inspiration, three in deep expiration). The maximal vertical motion of the superior pole from its end-expiratory to its end-inspiratory position is 39 mm (43 mm for the inferior pole). In deep inspiration or deep expiration the positions of the right and left kidneys appear reproducible. The mean deviation of kidney movement is less than 4 mm in all three dimensions (range, 0-6.9). For tumors close to the kidney, we advocate respiration gated radiation therapy so as to minimize the movement of this very radiosensitive structure.
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http://dx.doi.org/10.1016/0167-8140(94)90452-9 | DOI Listing |
J Chem Theory Comput
March 2025
Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States.
Protein evolution has shaped enzymes that maintain stability and function across diverse thermal environments. While sequence variation, thermal stability and conformational dynamics are known to influence an enzyme's thermal adaptation, how these factors collectively govern stability and function across diverse temperatures remains unresolved. Cytosolic malate dehydrogenase (cMDH), a citric acid cycle enzyme, is an ideal model for studying these mechanisms due to its temperature-sensitive flexibility and broad presence in species from diverse thermal environments.
View Article and Find Full Text PDFEURASIP J Audio Speech Music Process
March 2025
Centre for Digital Music, Queen Mary University of London, London, UK.
This paper introduces singing to speech conversion (S2S), a cross-domain voice conversion task, and presents the first deep learning-based S2S system. S2S aims to transform singing into speech while retaining the phonetic information, reducing variations in pitch, rhythm, and timbre. Inspired by the Glow-TTS architecture, the proposed model is built using generative flow, with an adjusted alignment module between the latent features.
View Article and Find Full Text PDFInt J Mol Sci
March 2025
Agricultural Information Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Feature engineering for whole-genome DNA sequences plays a critical role in predicting plant phenotypic traits. However, due to limitations in the models' analytical capabilities and computational resources, the existing methods are predominantly confined to SNP-based approaches, which typically extract genetic variation sites for dimensionality reduction before feature extraction. These methods not only suffer from incomplete locus coverage and insufficient genetic information but also overlook the relationships between nucleotides, thereby restricting the accuracy of phenotypic trait prediction.
View Article and Find Full Text PDFNihon Hoshasen Gijutsu Gakkai Zasshi
March 2025
Department of Radiology, Osaka Red Cross Hospital.
Purpose: We developed software that can analyze central lung distance (CLD) and central skin distance (CSD) in deep inspiration breath hold (DIBH) irradiation and verified the reproducibility of the DIBH irradiation method in our hospital.
Methods: CLD and CSD were analyzed using In-house software using cine images acquired during treatment; intra- or inter-fractional motion was calculated from the obtained data and compared with other reports using systematic error (ΔΣ) and random error (Δσ).
Results: The ΔΣ and Δσ were 1.
Sci Adv
March 2025
School of Science and Engineering, Chinese University of Hong Kong, Shenzhen, China.
Intrabronchial delivery of therapeutic agents is critical to the treatment of respiratory diseases. Targeted delivery is demanded because of the off-target accumulation of drugs in normal lung tissues caused by inhalation and the limited motion dexterity of clinical bronchoscopes in tortuous bronchial trees. Herein, we developed microrobotic swarms consisting of magnetic hydrogel microparticles to achieve intrabronchial targeted delivery.
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