The presence of clots or of a great amount of blood in the specimen from curettage or endometrial aspiration may lead to considerable problems for the pathologist. The application of a lysis buffer/ethanol solution before applying conventional fixation techniques may solve this problem. This new technique was tested on a series of endometrial samples. No disadvantages have been recorded, quite the contrary, optimum specimens were obtained for histochemical and immunohistochemical studies.
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