Two patients with heart failure and Cheyne-Stokes breathing are presented. We have discussed the possible physiopathological mechanism of Cheyne-Stokes breathing and clinical, instrumental and laboratory data for a correct diagnostic evaluation.
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Respir Res
January 2025
HP2 Laboratory, Inserm Unit 1300, University Grenoble Alpes, Grenoble, France.
The Alertapnée study followed 555 adults with obstructive sleep apnea treated with CPAP and found that the occurrence of Cheyne-Stokes respiration (CSR) was linked to a 14-fold increase in the risk of significant cardiac events (SCE) after one year. However, the progression and clinical significance of CSR episodes over time remain unclear. This ancillary study aimed to assess CSR progression and clinical outcomes during a second year of follow-up in 66 patients who had experienced at least one CSR episode in the first year.
View Article and Find Full Text PDFJ Clin Med
November 2024
Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, Clinic Floridsdorf, 1210 Vienna, Austria.
Impairment in autonomic activity is a prognostic marker in patients with heart failure (HF), and its involvement has been suggested in cardiovascular complications of obstructive sleep apnea syndrome (OSAS) and Cheyne-Stokes respiration (CSR). This prospective observational study aims to investigate the implications of sleep-disordered breathing (SDB) on hemodynamic regulation and autonomic activity in chronic HF patients. Chronic HF patients, providing confirmation of reduced ejection fraction (≤35%), underwent polysomnography, real-time hemodynamic, heart rate variability (HRV), and baroreceptor reflex sensitivity (BRS) assessments using the Task Force Monitor.
View Article and Find Full Text PDFJ Pain Symptom Manage
February 2025
Division of Palliative Medicine (P.W.), Department of Medicine, Washington University in St. Louis, St Louis, Missouri.
Context: Research has documented common respiratory changes at the end of life for hospice patients. Some studies have noted these symptoms as distressing and challenging for families, and as a potential reason for emergency room visits and hospice benefit revocation. However, the experiences and emotions of family members regarding these respiratory changes in the final days, particularly when they are alone in a home setting, are not well documented.
View Article and Find Full Text PDFEur Respir Rev
October 2024
University Hospital Essen, Ruhrlandklinik, Center for Sleep- and Telemedicine, Essen, Germany.
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View Article and Find Full Text PDFMath Biosci
December 2024
Center for Applied Medical Analytics, University of Virginia, Charlottesville, VA 240918, United States; Butterfly Dynamics LLC, 3017 Spotswood Cay, Williamsburg, VA 23185, United States. Electronic address:
Cheyne-Stokes Breathing is a periodic cycle of apnea followed by hyperventilation. A theory of this phenomenon is developed based on a minimal set of physiological assumptions. The rate of loss of CO from venous blood is proportional to the CO concentration in the lungs times the respiration rate; the respiration rate is a linear function of arterial CO concentration above a threshold, and zero below that threshold.
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