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The Role of Adjuvant Therapies in Improving Outcomes for pT1-3N0 Oral Squamous Cell Carcinoma With Tumour-Free Margins and Perineural Invasion.
Cureus
December 2024
Oral and Maxillofacial Surgery, ITS Dental College, Hospital and Research Centre, Greater Noida, IND.
Introduction The role of concomitant chemoradiation therapy (CTRT) or radiation therapy (RT) is not well defined in operated cases of oral squamous cell carcinoma (OSCC) with positive perineural spread. The purpose of the study was to determine whether the use of concurrent CTRT or RT would enhance the five-year disease-free survival of patients with positive perineural invasion (PNI). Materials and methods Data were analysed retrospectively from January 2014 to December 2023.
View Article and Find Full Text PDFA Rare Case of Salmonella Enteritidis Sinusitis.
Cureus
December 2024
Infectious Disease, Tan Tock Seng Hospital, Singapore, SGP.
Nontyphoidal is a common cause of gastroenteritis but can also lead to bacteremia and extraintestinal infections, including meningitis (more frequent in children and infants), endovascular infections (e.g., endocarditis and infected aneurysms), urinary tract infections, and bone or bone marrow infections (e.
View Article and Find Full Text PDFCompleting the Puzzle: Determinants, Comorbidities and Complications for Different Lung Cancer Subtypes: A Pilot Study.
Life (Basel)
December 2024
Pathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139 Targu Mures, Romania.
Background: Lung cancer remains one of the leading causes of cancer-related mortality worldwide, with multiple independent risk factors contributing to its development. The objective of this study was represented by the impact of independent risk factors, such as smoking, anemia, cachexia or COPD (chronic obstructive pulmonary disease) for lung cancer development.
Methods: We conducted a retrospective study, and we analyzed a database of 412 patients hospitalized between 1 February and 31 December 2023 in the Pulmonology Department of the Mureș County Clinical Hospital.
Pulmonary Mycobacterium malmoense Infection in a Patient with Non-small Cell Lung Cancer, Systemic Sclerosis, and Interstitial Pneumonia: A Case Report and Brief Review of the Literature.
Intern Med
January 2025
Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Japan.
A 69-year-old man with systemic sclerosis and interstitial pneumonia presented with an abnormal shadow in the right upper lung lobe. A thoracoscopic needle biopsy was performed on the right upper lobe lesion, and Mycobacterium malmoense was identified by 16S rRNA and rpoB gene sequencing. Surgical treatment was performed to obtain a radical cure, and lung squamous cell carcinoma and M.
View Article and Find Full Text PDFDNA methylation analysis from oral brushing reveals a field cancerization effect in proliferative verrucous leukoplakia.
Pathologica
December 2024
Functional and Molecular Neuroimaging Unit, Bellaria Hospital, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Objectives: The aim of the present study was to analyze the methylation status in patients who presented with an Oral Squamous Cell Carcinoma (OSCC) concomitantly with multifocal Proliferative Verrucous Leukoplakia (PVL)(PVL-OSCC).
Methods: Nine patients with OSCC and concomitant PVL lesions were selected. Two brushing samples were collected simultaneously from OSCC and PVL lesions in contralateral mucosa from each patient.
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