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Geospatial Agricultural Incident Analysis for the State of Indiana.
J Agric Saf Health
May 2024
Agricultural and Biological Engineering, Purdue University, West Lafayette, Indiana, USA.
Highlights: 29 recent agricultural-related fatalities or injuries occurring throughout the state of Indiana were analyzed using geospatial incident analysis. Proximity of each incident to nearby cellular towers was found through 5 and 10-mile spatial joins by their relationship with cellular towers, with no towers most likely to be found within 5 miles of a given incident and only one tower to be found within 10 miles of a given incident. Proximity of each incident to emergency services and the nearest hospital was performed through 5 and 10-mile spatial joins, with only one service provider most likely to be within the five-mile range of a given incident.
View Article and Find Full Text PDFChallenges and Revisions in Diagnostic Criteria: Advancing Early Detection of Prion Diseases.
Int J Mol Sci
February 2025
Unit of Medical and Dental Sciences, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.
Prion diseases are fatal neurological disorders characterized by abnormal protein accumulation in the brain, leading to neurodegeneration, dementia, and ataxia. Sporadic Creutzfeldt-Jakob disease (sCJD), the most common form, accounts for 80-90% of cases and progresses rapidly, with most patients surviving <6 months to a year after symptom onset, indicating the importance of early diagnosis. The disease is classified into six subtypes based on PRNP gene polymorphisms, with differences in protein degradation patterns contributing to the diversity of clinical symptoms.
View Article and Find Full Text PDFLow Intratumoral CD200 Protein Expression in Primary Merkel Cell Carcinoma Is a Strong Predictor for Disease Relapse.
Cancers (Basel)
February 2025
Department of Plastic, Reconstructive and Aesthetic Surgery, Hand Surgery, Fachklinik Hornheide, 48157 Munster, Germany.
Background: Merkel cell carcinoma (MCC) is a rare and frequently fatal form of skin cancer. Apart from Programmed Cell Death Protein 1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) signaling, there is a lack of knowledge regarding other immune checkpoint molecules. Recent studies have observed elevated glycoprotein CD200 (also known as OX-2) mRNA expression in in different types of tumors, with CD200R-expressing myeloid cells present in the tumor microenvironment.
View Article and Find Full Text PDFTargeting the Leukemia Inhibitory Factor/Leukemia Inhibitory Factor Receptor Axis Reduces the Growth of Inflammatory Breast Cancer by Promoting Ferroptosis.
Cancers (Basel)
February 2025
Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Inflammatory breast cancer (IBC) is a rare subtype of breast cancer accounting for 7% of breast cancer-related fatalities. There is an urgent need to develop new targeted treatments for IBC. The progression of IBC has been associated with alterations in growth factor and cytokine signaling; however, the function of the LIF (leukemia inhibitory factor)/LIFR (leukemia inhibitory factor receptor) cytokine pathway in the progression of IBC remains unknown.
View Article and Find Full Text PDFLumbar round cell sarcoma in a 10-week-old rottweiler puppy.
Acta Vet Scand
March 2025
Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlaegevej 16, Frederiksberg C, DK-1870, Denmark.
Background: Spinal neoplasms are sparsely documented in juvenile dogs. Case reports and small case series have described nephroblastomas, primitive neuroectodermal tumours, gliomas, certain sarcomas, and osteochondromas, but round cell sarcomas have not previously been documented.
Case Presentation: This case report describes a 10-week-old female Rottweiler puppy with acute onset of progressive ataxia and pelvic limb lameness.
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