This study examines internal state words in mothers' speech to children with Down syndrome, and the relation between the use of internal state words and the children's levels of social-adaptive, communicative, and linguistic functioning. Results indicate qualitative differences in mothers' use of internal state words to children with children Down syndrome, compared with a sample of maternal speech to nonhandicapped children who were matched on the Vineland scales for their level of adaptive functioning. Differences include use of fewer internal state words overall to children with Down syndrome, and different kinds of internal state words: more words referring to physiological states, and fewer words referring either to affect or to cognition. In general, child Mean Length of Utterance (MLU) was associated with the pattern of inner state words used by mothers, whereas no associations were found between children's social-adaptive competence and maternal input. Even when controlling for child MLU, there were, however, some qualitative differences in the inner state lexicons used to children with Down syndrome. Results suggest that speech to children with Down syndrome that is calibrated to their MLU may underestimate their competence in domains other than grammar.
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http://dx.doi.org/10.1016/0021-9924(94)90038-8 | DOI Listing |
Invest Ophthalmol Vis Sci
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Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
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View Article and Find Full Text PDFMinerva Anestesiol
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Pain Management Center, Neurocenter of Southern Switzerland, EOC, Lugano, Switzerland -
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Internal Medicine, Jilin Cancer Hospital, Changchun, China.
Purpose: This phase II study is designed to evaluate the combination therapy involving suvemcitug and envafolimab with FOLFIRI in microsatellite-stable or mismatch repair-proficient (MSS/pMMR) colorectal cancer (CRC) in the second-line treatment setting.
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Int J Legal Med
January 2025
Unit of Forensic Medicine, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Pathology has benefited from the rapid progress of image-digitizing technology during the last decade. However, the application of digital whole slide images (WSI) in forensic pathology still needs to be improved. WSI validation is crucial to ensure diagnostic performance, at least equivalent to glass slides and light microscopy.
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Wayne State University, Division of Pulmonary, Critical Care and Sleep Medicine, Detroit, Michigan, United States;
Numerous chronic human disorders are associated with immune activation by obscure antigen(s). We identified a novel sarcoidosis-epitope (ChainA) by immunoscreening of a novel T7 phage library and confirmed an abundance of ChainA IgG-antibody in sarcoidosis. We tested whether ChainA epitope elicits immune responses through B-cell activation, plasma cell differentiation and antibody production.
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