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The binuclear cyclopalladated complex CP2 is targeting ubiquinol-cytochrome c reductase (complex III) of Leishmania amazonensis.
Int J Parasitol Drugs Drug Resist
December 2024
São Paulo State University (Unesp), School of Pharmaceutical Sciences, Araraquara, São Paulo, Brazil. Electronic address:
Leishmaniasis is a neglected disease that remains with a limited number of drugs available for chemotherapy and has an increased drug resistance that affects treatment outcomes. Metal-based drugs such as cyclopalladated complex [Pd(dmba)(μ-N)] (CP2), a Leishmania topoisomerase IB inhibitor involved in calcium dysregulation and mitochondrial dysfunction of the parasite, had been an alternative to outline the appearance of chemoresistance. To identify new molecular targets and point out possible resistance mechanisms, a CP2-resistant Leishmania amazonensis (LaR) was selected by stepwise exposure to increasing drug pressure until a line capable of growth in 13.
View Article and Find Full Text PDFStudies of the FBT family transporters in Leishmania infantum by gene deletion and protein localization.
Exp Parasitol
January 2025
Centre de Recherche en Infectiologie du Centre de Recherche du CHU de Québec and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Quebec City, Québec, Canada. Electronic address:
The protozoan parasite Leishmania has a large family of major facilitator membrane proteins part of the Folate Biopterin Transporter (FBT) family. The chromosome 10 of Leishmania has a cluster of 7 FBT genes including the S-Adenosyl methionine (AdoMet) transporter and the functionally characterized folate transporters FT1 and FT5. Six of the 7 FBT proteins coded by this locus are located at the plasma membrane as determined by gene fusions with the green fluorescent protein.
View Article and Find Full Text PDFChemotherapy for the treatment of alveolar echinococcosis: Where are we?
Parasite
September 2024
Université de Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
Article Synopsis
- Alveolar echinococcosis (AE) is a serious liver disease caused by a parasite called Echinococcus multilocularis.
- The main treatment involves using certain medications called benzimidazoles, which can help but may not work if treatment is stopped, and can also hurt the liver.
- There are other potential treatments, but they often have side effects or are not proven to work well, so researchers are looking for better solutions.
Combination of compound screening with an animal model identifies pentamidine to prevent Chlamydia trachomatis infection.
Cell Rep Med
July 2024
Department of Dermatology, Medical University of Vienna, Vienna 1090, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna 1090, Austria. Electronic address:
Chlamydia trachomatis (Ct) is the most common cause for bacterial sexually transmitted infections (STIs) worldwide with a tremendous impact on public health. With the aim to unravel novel targets of the chlamydia life cycle, we screen a compound library and identify 28 agents to significantly reduce Ct growth. The known anti-infective agent pentamidine-one of the top candidates of the screen-shows anti-chlamydia activity in low concentrations by changing the metabolism of host cells impairing chlamydia growth.
View Article and Find Full Text PDFLactobacilli decrease the susceptibility of Typhimurium to azithromycin.
Microbiol Spectr
August 2024
Département de biologie, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Bacteria are involved in numerous interactions during infection and among host-associated microbial populations. serovar Typhimurium is a foodborne pathogen of great importance as well as a model organism to study interactions within a microbial community. In this study, we found that .
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