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The TOXIN knowledge graph: supporting animal-free risk assessment of cosmetics.
Database (Oxford)
January 2025
Department of In Vitro Toxicology and Dermato-Cosmetology (IVTD), Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels 1090, Belgium.
The European Union's ban on animal testing for cosmetic products and their ingredients, combined with the lack of validated animal-free methods, poses challenges in evaluating their potential repeated-dose organ toxicity. To address this, innovative strategies like Next-Generation Risk Assessment (NGRA) are being explored, integrating historical animal data with new mechanistic insights from non-animal New Approach Methodologies (NAMs). This paper introduces the TOXIN knowledge graph (TOXIN KG), a tool designed to retrieve toxicological information on cosmetic ingredients, with a focus on liver-related data.
View Article and Find Full Text PDFUrgent call: Environmental mismanagement after historical flood amplifies Rio Grande do Sul's ecological crisis in south of Brazil.
An Acad Bras Cienc
January 2025
Universidade Federal do Rio Grande do Sul, Faculdade de Farmácia, Av. Ipiranga, 2752, Azenha, 90610-000 Porto Alegre, RS, Brazil.
Donor-derived Cryptococcus gattii complex infection after liver transplantation.
Rev Soc Bras Med Trop
January 2025
Universidade Federal do Paraná, Departamento de Clínica Médica, Programa de pós-graduação em Medicina Interna e Ciências da Saúde, Curitiba, PR, Brasil.
Cryptococcal disease is the third most common invasive fungal infection in solid organ transplant recipients and is associated with high-morbidity and -mortality rates. Donor-derived Cryptococcus spp. infection typically manifests within the first month post-procedure and has historically been caused by C.
View Article and Find Full Text PDF[Self-government processes of mothers in the context of the Brazilian Rede Cegonha Program].
Cien Saude Colet
January 2025
Departamento de Saúde Coletiva, Faculdade de Ciências Médicas, Unicamp. Campinas SP Brasil.
The study highlights the discourses produced by mothers and professionals from the Rede Cegonha Program of the Brazilian Ministry of Health in the relationship between the body, women and public health policies on labor and birth. For this purpose, 17 semi-structured interviews were conducted and categorized in the Rede Cegonha Program, body and woman, and submitted to Foucauldian discourse analysis, processes of subjectification (resistance and subjection) and biopolitics. The data revealed: i) the relevance of a public program for this purpose; ii) the centrality of the pregnant body and the historical challenge of understanding women as mothers beyond reproduction; iii) the idea of defective bodies and resistance of those who know how to give birth; and iv) the possibilities of self-government of mothers and, consequently, the production of the self based on the experiences reported.
View Article and Find Full Text PDFDog skull shape challenges assumptions of performance specialization from selective breeding.
Sci Adv
January 2025
Schmid College of Science and Technology, Chapman University, Orange, CA 92866, USA.
Through selective breeding, humans have driven exceptional morphological diversity in domestic dogs, creating more than 200 recognized breeds developed for specialized functional tasks such as herding, protection, and hunting. Here, we use three-dimensional reconstructions of dog skulls to ask whether these function-oriented kennel-club groups reflect differences in morphology that correspond to those functions. We analyzed 117 canid skulls, representing 40 domestic dog breeds and 18 wild subspecies, using geometric morphometric techniques and -means clustering.
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