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Chemerin and Polycystic Ovary Syndrome: A Comprehensive Review of Its Role as a Biomarker and Therapeutic Target.
Biomedicines
December 2024
Department of Experimental and Clinical Medicine, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
Chemerin, an adipokine implicated in inflammatory, metabolic, and adipogenic processes, has been detected in high serum concentration in women with polycystic ovary syndrome (PCOS) and seems to play a role in PCOS pathogenesis. Moreover, at present, no comprehensive and critical document is available in the literature on this topic. The aim of the current study was to comprehensively review the latest available data to confirm the evidence about the association between chemerin and PCOS, highlighting its potential role as an upcoming biomarker and therapeutic target.
View Article and Find Full Text PDFNicotinamide Mononucleotide Alleviates Bile Acid Metabolism and Hormonal Dysregulation in Letrozole-Induced PCOS Mice.
Biology (Basel)
December 2024
School of Medicine, Jiangsu University, Zhenjiang 212013, China.
Polycystic ovary syndrome (PCOS) involves complex genetic, metabolic, endocrine, and environmental factors. This study explores the effects of nicotinamide mononucleotide (NMN) in a letrozole-induced PCOS mouse model, focusing on metabolic regulation. Letrozole-induced aromatase inhibition elevated androgen and reduced bile acid levels, linking liver dysfunction and gut imbalance to PCOS.
View Article and Find Full Text PDFButyrate-Mediated Modulation of Paraoxonase-1 Alleviates Cardiorenometabolic Abnormalities in a Rat Model of Polycystic Ovarian Syndrome.
Cardiovasc Drugs Ther
November 2024
Department of Chemical Pathology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Article Synopsis
- Polycystic ovarian syndrome (PCOS) is linked to increased cardiovascular risks and cardiorenal disorders, and the study explores how short-chain fatty acids (SCFAs), particularly butyrate, may influence these conditions.
- * The research involved administering letrozole to induce PCOS in rats, followed by treatment with butyrate, leading to observations of various metabolic, cardiac, and renal abnormalities in PCOS rats.
- * Results indicated that butyrate treatment significantly improved systemic and cardiorenal health markers while boosting paraoxonase-1 (PON-1) levels, suggesting its potential as a therapeutic option for managing heart and kidney issues in PCOS.
Rethinking the Terminology: A Perspective on Renaming Polycystic Ovary Syndrome for an Enhanced Pathophysiological Understanding.
Clin Med Insights Endocrinol Diabetes
October 2024
Department of Endocrinology, University Hospital of Farhat Hached Sousse, Tunisia.
Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder that affects women at various stages of life, presenting a wide range of symptoms and health implications. The term "Polycystic Ovary Syndrome" can be misleading, prompting many within the medical community and advocacy groups to advocate for a name change. Critics argue that this terminology can complicate understanding and awareness of the disease among patients.
View Article and Find Full Text PDFObjectives: Combined oral contraceptives are used for the management of hyperandrogenism and menstrual abnormalities in polycystic ovary syndrome (PCOS). There is a dearth of literature addressing the effect of ethinyl estradiol/norethisterone acetate (EE/NETA) on gingival and systemic inflammation in these patients. This randomized trial aimed to evaluate the effect of EE/NETA with and without scaling on periodontium and high-sensitivity C-reactive protein (hsCRP) levels in women with PCOS having gingivitis.
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