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Efficacy and safety of androgen receptor inhibitors for treatment of advanced prostate cancer: A systematic review and network meta-analysis.
Br J Clin Pharmacol
September 2024
School of Chemical Engineering, Ocean and Life Sciences, Dalian University of Technology, Panjin, China.
Aims: Androgen receptor inhibitors (ARIs) have become an effective treatment for advanced prostate cancer (PC). However, it is unknown which ARI is the most helpful and safe for men with advanced PC. Our aim is to help physicians make clinical decisions and provide medication guidelines for patients with advanced PC to avoid potential risks when using ARIs for treatment.
View Article and Find Full Text PDFSafety of Antiandrogens for the Treatment of Female Androgenetic Alopecia with Respect to Gynecologic Malignancies.
J Clin Med
May 2024
Department of Dermatology, Inselspital, Bern University Hospital, 3010 Bern, Switzerland.
Article Synopsis
- Female androgenetic alopecia (FAGA) is the most common type of hair loss in women, showing a patterned progression in hair thinning.
- Various oral treatments, including spironolactone and reduced androgen activity medications, can help manage FAGA, but concerns exist about their use in women with past gynecological cancers.
- A review indicates that spironolactone is generally safe for treating FAGA, even for high-risk patients, but more research is needed to determine the safety of other treatments for those with gynecologic cancer histories.
Determination of enzalutamide long-term safety and efficacy for castration-resistant prostate cancer patients after combined anti-androgen blockade followed by alternative anti-androgen therapy: a multicenter prospective DELC study.
Jpn J Clin Oncol
May 2024
Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Article Synopsis
- The DELC study aimed to evaluate the effectiveness of enzalutamide in treating Japanese patients with castration-resistant prostate cancer after they failed previous treatment with bicalutamide and switched to flutamide.
- Key findings showed a 72.2% reduction in prostate-specific antigen levels and a median overall survival of 42.05 months, with certain serum levels identified as independent risk factors for survival.
- Common side effects of enzalutamide included fatigue, constipation, and appetite loss, with adherence to the treatment declining in patients over 70 years old.
Dose addition in mixtures of compounds with dissimilar endocrine modes of action in in vitro receptor activation assays and the zebrafish sexual development test.
Food Chem Toxicol
February 2024
Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA, Bilthoven, the Netherlands.
Background: Human exposure to pesticides is being associated with feminisation for which a decrease of the anogenital distance (AGD) is a sensitive endpoint. Dose addition for the cumulative risk assessment of pesticides in food is considered sufficiently conservative for combinations of compounds with both similar and dissimilar modes of action (MoA).
Objective: The present study was designed to test the dose addition hypothesis in a binary mixture of endocrine active compounds with a dissimilar mode of action for the endpoint feminisation.
Efficacy and safety of anti-androgens in the management of polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials.
EClinicalMedicine
September 2023
Monash Centre for Health Research and Implementation (MCHRI), Monash University, Clayton, VIC, Australia.
Background: Anti-androgens and combined oral contraceptive pills (COCPs) may mitigate hyperandrogenism-related symptoms of polycystic ovary syndrome (PCOS). However, their efficacy and safety in PCOS remain unclear as previous reviews have focused on non-PCOS populations. To inform the 2023 International Evidence-based Guideline in PCOS, we conducted the first systematic review and meta-analysis investigating the efficacy and safety of anti-androgens in the management of hormonal and clinical features of PCOS.
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