Muscle fatigue and lack of endurance are complaints of persons with chronic low back pain, but there are no standard ways to assess endurance in this population. The purposes of this study were to examine three measures of endurance; to determine relationships of these measures to each other; and to describe effects of gender, obesity, smoking, and self-reported fitness on the clinical measures. The measures of endurance selected were not dependent on maximal voluntary muscular contractions. They were the Sorensen test, median frequency decline of selected muscles, and a submaximal bicycle ergometer test. Thirty-five consenting individuals who were referred for treatment answered questions about their daily exercise prior to being tested. Repeatability of the Sorensen test holding time and of the slope measure of decline in the median frequencies was acceptable for subjects who reported a higher activity level. The decline of the median frequency in the biceps femoris muscles correlated with holding time of the Sorensen test. Smoking, gender, or obesity level did not affect test results on any of the endurance measures. Subjects who reportedly were more active achieved significantly higher scores on the Sorensen test. The importance of controlling for self-perception of activity in physical testing is discussed.
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http://dx.doi.org/10.2519/jospt.1994.20.2.81 | DOI Listing |
J Psychiatr Res
January 2025
VIVE - The Danish Center for Social Science Research, Denmark. Electronic address:
Introduction: Research on the long-term effects of treatment for attention deficit hyperactivity disorder (ADHD) on educational and social outcomes is limited. This study aims to evaluate long-term social functioning outcomes in patients with ADHD and the potential effects of pharmacological treatment for ADHD.
Methods: We used National Patient Registry data from 1995 to 2016 to identify patients diagnosed with ADHD and those collecting ADHD medication.
Clin Pharmacol Ther
January 2025
Center for Observational Research, Amgen Inc., Thousand Oaks, California, USA.
A compilation of factors over the past decade-including the availability of increasingly large and rich healthcare datasets, advanced technologies to extract unstructured information from health records and digital sources, advancement of principled study design and analytic methods to emulate clinical trials, and frameworks to support transparent study conduct-has ushered in a new era of real-world evidence (RWE). This review article describes the evolution of the RWE era, including pharmacoepidemiologic methods designed to support causal inferences regarding treatment effects, the role of regulators and other health authorities in establishing distributed real-world data networks enabling analytics at scale, and the many global guidance documents on principled methods of producing RWE. This article also highlights the growing opportunity for RWE to support decision making by regulators, health technology assessment groups, clinicians, patients, and other stakeholders and provides examples of influential RWE studies.
View Article and Find Full Text PDFTransfusion
January 2025
Department of Clinical Immunology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Background: We aimed to investigate if iron deficiency was associated with infection susceptibility in a large cohort of healthy individuals.
Study Design And Methods: The Danish Blood Donor Study is a national ongoing prospective study of blood donors. We included 94,628 donors with 338,290 ferritin measurements from March 2010 to October 2022.
Microorganisms
December 2024
Department for Sustainability, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, ENEA Casaccia Research Center, 00123 Rome, RM, Italy.
For the safe use of microbiome-based solutions in agriculture, the genome sequencing of strains composing the inoculum is mandatory to avoid the spread of virulence and multidrug resistance genes carried by them through horizontal gene transfer to other bacteria in the environment. Moreover, the annotated genomes can enable the design of specific primers to trace the inoculum into the soil and provide insights into the molecular and genetic mechanisms of plant growth promotion and biocontrol activity. In the present work, the genome sequences of some members of beneficial microbial consortia that have previously been tested in greenhouse and field trials as promising biofertilizers for maize, tomato and wheat crops have been determined.
View Article and Find Full Text PDFJ Electromyogr Kinesiol
December 2024
Department of Neurology, Center for Neuromuscular Diseases (Associated National Center in the European Reference Network ERN EURO-NMD), University Hospital Brno, Brno, Czechia; Faculty of Medicine, Masaryk University, Brno, Czechia; Department of Rehabilitation, University Hospital Brno, Brno, Czechia; Department of Public Health, Faculty of Medicine, Masaryk University, Brno, Czechia.
The purpose of this cross-sectional study was to present the values of maximal isometric lumbar extensor muscle strength (MILEMS) and lumbar extensor muscle endurance (LEME) in healthy subjects and to study the influence of physiological factors on these parameters. MILEMS using a hand-held dynamometer in three positions (prone, sitting, standing) and LEME using the Biering-Sørensen test were assessed in 115 healthy volunteers. The MILEMS measurements for the specific positions were correlated with each other (Pearson correlation coefficients 0.
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