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Influence of ABCB1 polymorphisms on aripiprazole and dehydroaripiprazole plasma concentrations.
Sci Rep
January 2025
Pharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706, Santiago de Compostela, Spain.
Aripiprazole (ARI) is an atypical antipsychotic which is a substrate of P-glycoprotein (P-gp), a transmembrane glycoprotein that plays a crucial role in eliminating potentially harmful compounds from the organism. ARI once-monthly (AOM) is a long-acting injectable form which improves treatment compliance. Genetic polymorphisms in ABCB1 may lead to changes in P-gp function, leading to individual differences in drug disposition.
View Article and Find Full Text PDFDetermination of Nemonoxacin in Small Volumes of Rat Plasma and Bile by a Novel HPLC-Fluorescence Assay and Its Application to Disposition and Biliary Excretion Kinetics.
Drug Des Devel Ther
December 2024
Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan City, Taiwan.
Background: Nemonoxacin is a novel non-fluorinated quinolone antibiotic for the treatment of community-acquired pneumonia. To investigate the pharmacokinetics (PK) of nemonoxacin, a simple and sensitive high-performance liquid chromatography assay (HPLC) was needed.
Methods: An HPLC method with fluorescence (FL) detection was developed for the quantification of nemonoxacin in plasma and bile.
Synthesis of Ethyl Pyrimidine-Quinolincarboxylates Selected from Virtual Screening as Enhanced Lactate Dehydrogenase (LDH) Inhibitors.
Int J Mol Sci
September 2024
Facultad de Ciencias Experimentales, Departamento de Química Inorgánica y Orgánica, Universidad de Jaén, E-23071 Jaén, Spain.
Article Synopsis
- * Researchers designed a novel family of compounds using virtual docking to enhance the inhibition of hLDHA through a specific synthetic pathway involving ethyl pyrimidine-quinolinecarboxylate derivatives.
- * Out of the synthesized inhibitors, 13 demonstrated potent effects with IC values lower than 5 μM, and selectivity testing showed that some were selective for the hLDHA isoform over hLDHB, marking them as potential therapeutic agents.
Population pharmacokinetics of amodiaquine and piperaquine in African pregnant women with uncomplicated Plasmodium falciparum infections.
CPT Pharmacometrics Syst Pharmacol
November 2024
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Article Synopsis
- * This study looked at the pharmacokinetics (how the drugs move and are processed in the body) of amodiaquine, desethylamodiaquine, and piperaquine in pregnant women during their second and third trimesters with uncomplicated malaria.
- * Results showed that while amodiaquine's absorption increased with gestational age, the exposure to desethylamodiaquine and piperaquine in pregnant women was similar to that in non-pregnant women, indicating that dose adjustments are unnecessary for these patients.
Effect of Salbutamol on the Disposition Kinetics of Levofloxacin in the Plasma and Lung of Rats.
Curr Drug Metab
November 2024
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Mustafa Kemal University, Hatay, 31100, Turkiye.
Background: Antibiotics and bronchodilator drugs can be used together in respiratory distress caused by bacterial infections. Levofloxacin (LVX) and Salbutamol (SLB) can be used simultaneously in respiratory distress. However, there have been no investigations on how the concurrent use of SLB can affect the pharmacokinetics of LVX in rats.
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