Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Network Pharmacology and Molecular Docking Study on the Mechanism of the Therapeutic Effect of Strychni Semen in NSCLC.
Biol Proced Online
December 2024
Department of Radiation Oncology, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu, China.
Article Synopsis
- Strychni Semen has shown anti-tumor properties against non-small cell lung cancer (NSCLC), but its molecular mechanisms require further investigation.
- The study utilized network pharmacology and molecular docking to identify 21 active components and 67 targets related to NSCLC, with key findings showing strong interactions between the components and core targets such as PTGS2 and NR3C1.
- Pathway analysis indicated that Strychni Semen's therapeutic effects on NSCLC primarily involve the Calcium, Estrogen, and cGMP-PKG/cAMP pathways, helping to elucidate its underlying mechanisms of action.
Transcriptome, network analysis, and molecular docking approaches to elucidate the modes of action of Astragaloside IV against myocardial infarction with mitochondrial energy metabolism network-targeted regulation.
Comput Biol Med
October 2023
Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. Electronic address:
Article Synopsis
- Mitochondria are critical for heart energy metabolism, and targeting this metabolism could help treat ischemic heart disease (IHD) using astragaloside IV (AST).
- Researchers used various methods, including data collection on genes, network analysis, and molecular docking, to identify potential targets of AST related to mitochondrial energy metabolism in IHD.
- The study found 1713 IHD-related genes, 528 related to energy metabolism, and identified key targets of AST, showing promising binding affinities and potential pathways involved in regulating these targets in the context of IHD.
Cranial anatomy and phylogenetic affinities of Bolosaurus major, with new information on the unique bolosaurid feeding apparatus and evolution of the impedance-matching ear.
Anat Rec (Hoboken)
July 2024
Department of Earth and Planetary Sciences, Yale University, New Haven, Connecticut, USA.
Resolving the phylogenetic relationships of early amniotes, in particular stem reptiles, remains a difficult problem. Three-dimensional morphological analysis of well-preserved stem-reptile specimens can reveal important anatomical data and clarify regions of phylogeny. Here, we present the first thorough description of the unusual early Permian stem reptile Bolosaurus major, including the first comprehensive description of a bolosaurid braincase.
View Article and Find Full Text PDFCyclopropanation and membrane unsaturation improve antibiotic resistance of swarmer Pseudomonas and its sod mutants exposed to radiations, in vitro and in silico approch.
World J Microbiol Biotechnol
June 2024
Laboratoire de Traitement des Eaux Usées, Centre de Recherches et Technologies des Eaux Usées, Technopole Borj Cedria, BP 273, 8020, Soliman, Tunisia.
It was known that UVc irradiation increases the reactive oxygen species' (ROS) levels in bacteria hence the intervention of antioxidant enzymes and causes also changes in fatty acids (FAs) composition enabling bacteria to face antibiotics. Here, we intended to elucidate an interrelationship between SOD and susceptibility to antibiotics by studying FA membrane composition of UVc-treated P. aeruginosa PAO1 and its isogenic mutants (sodM, sodB and sod MB) membrane, after treatment with antibiotics.
View Article and Find Full Text PDFLC-MS/MS profiling of Tipuana tipu flower, HPLC-DAD quantification of its bioactive components, and interrelationships with antioxidant, and anti-inflammatory activity: in vitro and in silico approaches.
BMC Complement Med Ther
April 2024
Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr-El-Ainy Street, Cairo, 11562, Egypt.
Background: Fabaceae plays a crucial role in African traditional medicine as a source of large number of important folk medication, agriculture and food plants. In a search of potential antioxidant and anti-inflammatory candidates derived from locally cultivated plants, the flowers of Tipuana tipu (Benth.) Lillo growing in Egypt were subjected to extensive biological and phytochemical studies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!