AI Article Synopsis
- The Eker rat serves as an effective animal model for studying cancer predisposition syndromes.
- Researchers have identified a new genetic linkage between rat chromosome 10q and human chromosome 16p13.3, indicating a connection to the tuberous sclerosis (TSC2) gene.
- This discovery marks an important step toward isolating and identifying the specific Eker mutation responsible for cancer predisposition.
Article Abstract
The Eker rat is a promising animal model of cancer predisposition syndromes. In this study, using 129 backcross animals, we have established a new conserved linkage group on rat 10q and human 16p13.3 whereby the Eker mutation was found to be tightly linked to the tuberous sclerosis (TSC2) gene. This will be the first step toward the positional cloning and identification of the predisposing Eker mutation.
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| http://dx.doi.org/10.1006/bbrc.1994.2324 | DOI Listing |
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