A study was undertaken of the prevalence of physical disease, psychiatric disorder and deviant behaviour in a sample of 137 long stay psychiatric patients at Porirua Hospital near Wellington, New Zealand. Patients were in the main male, single, middle-aged to elderly and of European descent. Schizophrenia was the most common diagnosis. Psychiatric symptoms were moderately severe, the most common being unusual mannerisms and posturing, anxiety, blunted affect, tension, unusual thought content and somatic concerns. Known physical disorders were present in 66 patients. Levels of neuroleptic medication were high and tardive dyskinesia was observed in almost 60% of patients. Frequency of deviant behaviour was low in absolute terms but nonetheless problematic. The frequency of deviant behaviour was similar to those reported for British patients.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.3109/00048679309075820 | DOI Listing |
Neuropharmacology
January 2025
Division of Molecular Psychiatry, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.
While healthy brain function relies on a dynamic but tightly regulated interaction between excitation (E) and inhibition (I), a spectrum of social cognition disorders, including antisocial behavior and antisocial personality disorder (ASPD), frequently ensuing from irregular neurodevelopment, may be associated with E/I imbalance and concomitant alterations in neural connectivity. Technological advances in the evaluation of structural and functional E/I balance proxies in clinical settings and in human cell culture models provide a general basis for identification of biomarkers providing a powerful concept for prevention and intervention across different dimensions of mental health and disease. In this perspective we outline a framework for research to characterize neurodevelopmental pathways to antisocial behavior and ASPD driven by (epi)genetic factors across life, and to identify molecular targets for preventing the detrimental effects of cognitive dysfunction and maladaptive social behavior, considering psychosocial experience; to validate signatures of E/I imbalance and altered myelination proxies as biomarkers of pathogenic neural circuitry mechanisms to determine etiological processes in the transition from mental health to antisocial behavior and ASPD and in the switch from prevention to treatment; to develop a neurobiologically-grounded integrative model of antisocial behavior and ASPD resultant of disrupted E/I balance, allowing to establish objective diagnoses and monitoring tools, to personalize prevention and therapeutic decisions, to predict treatment response, and thus counteract relapse; and finally, to promote transformation of dimensional disorder taxonomy and to enhance societal awareness and reception of the neurobiological basis of antisocial behavior and ASPD.
View Article and Find Full Text PDFEur J Neurosci
January 2025
Department of Psychology and Cognitive Sciences (DiPSCo), University of Trento, Trento, Italy.
The Dark Triad (DT), encompassing narcissism, Machiavellianism and psychopathy traits, poses significant societal challenges. Understanding the neural underpinnings of these traits is crucial for developing effective interventions and preventive strategies. Our study aimed to unveil the neural substrates of the DT by examining brain scans from 201 individuals (mean age: 32.
View Article and Find Full Text PDFInt J Offender Ther Comp Criminol
January 2025
University of Alabama, Tuscaloosa, AL, USA.
The Proposed Specifiers for Conduct Disorder (PSCD) is a promising novel scale that measures psychopathic traits and includes an additional conduct disorder factor that taps the antisocial dimension of psychopathy. The current study sought to broaden the application of PSCD by examining the factor structure, convergent and discriminant validity, and connections to delinquency in a young adult sample ( = 450; = 31.91 years, = 13.
View Article and Find Full Text PDFPersonal Disord
January 2025
School of Social Work and Criminology, Université Laval.
Studies that focus on whether psychopathy statistically predicts reoffending are not informative of the process that connects the putative cause (psychopathy) to the expected outcome (offending). Understanding the causal mechanisms responsible for the relationship between psychopathy and offending has received minimal empirical attention even though fourth-generation risk assessment protocols and treatment strategies regularly require a specific focus on psychopathy. Theory can help guide an improved understanding of the causal mechanisms underlying the relationship between psychopathy and offending.
View Article and Find Full Text PDFReports of sex and age differences in the presentation of borderline symptoms have been limited to the Western literature and have not systematically compared adolescents with emerging and older adults with borderline personality disorder (BPD). This study aimed to examine the impact of age and sex on the expression of borderline symptoms in adolescents, young adults, and older adults with BPD. A sample of 493 Iranian individuals with a confirmed diagnosis of BPD was segregated into 2 age groups: 134 young people aged 12-25 (mean = 17.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!