AI Article Synopsis
- The authors identified five unique probes specific to the X chromosome from a specialized library.
- They used hybrid cell lines from patients with X-autosome translocations to map the probes' locations on the X chromosome.
- Three probes were found between the regions Xq23 and Xq26, while two were located between Xp21 and Xp11.2, with one probe showing a TaqI polymorphism.
Article Abstract
The authors isolated five single-copy X-specific probes from an X-enriched library. These probes were regionally localized on the X chromosome by using somatic hybrid cell lines obtained from patients carrying different X-autosome translocations. Three clones were located between Xq23 and Xq26, the two others were mapped between Xp21 and Xp11.2. Analyses with different restriction enzymes indicated that one of them detects a TaqI polymorphism with a polymorphism information content (PIC) of 0.28.
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