AI Article Synopsis
- - Serum soluble intercellular adhesion molecule-1 (sICAM-1) levels were found to be significantly higher in asthmatic patients not on steroid therapy compared to healthy subjects and those on steroids.
- - During asthma attacks, sICAM-1 levels increased in patients compared to when they were in remission, suggesting an association with asthma exacerbation.
- - The exact source of sICAM-1 in asthmatic patients is uncertain, but increased ICAM-1 expression in the respiratory tract may play a role in attracting immune cells that contribute to airway inflammation in asthma.
Article Abstract
Serum soluble intercellular adhesion molecule-1 (sICAM-1) levels were measured in 54 asthmatic patients and 32 healthy subjects by sandwich enzyme-linked immunosorbent assay. Serum sICAM-1 levels in the asthmatic patients not undergoing steroid therapy were significantly higher than those in the healthy subjects and those in the asthmatic patients undergoing steroid therapy (p < 0.01 and p < 0.001, respectively). Serum sICAM-1 levels in the asthmatic patients during attack were not significantly different from those in the patients in remission. We studied changes in serum ICAM-1 levels in 13 asthmatic patients in remission and during attack and found that serum ICAM-1 levels during attack were significantly higher than those in remission (p < 0.05). The origin of serum soluble ICAM-1 in asthmatic patients still remains unclear, but the up-regulated expression of ICAM-1 on the endothelium of the respiratory tract may contribute to the recruitment of eosinophils, neutrophils and lymphocytes to the airway in bronchial asthma.
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