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Analysis and Imaging of Osteocytes.
J Vis Exp
November 2024
Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City;
Osteocytes are the bone cells that are thought to respond to mechanical strains and fluid flow shear stress (FFSS) by activating various biological pathways in a process known as mechanotransduction. Confocal image-derived models of osteocyte networks are a valuable tool for conducting Computational Fluid Dynamics (CFD) analysis to evaluate shear stresses on the osteocyte membrane, which cannot be determined by direct measurement. Computational modeling using these high-resolution images of the microstructural architecture of bone was used to numerically simulate the mechanical loading exerted on bone and understand the load-induced stimulation of osteocytes.
View Article and Find Full Text PDFEarly and late postnatal lung distribution of collagen type VI in preterm and term infants.
Respir Physiol Neurobiol
January 2025
Department of Women's and Children's Health, Uppsala University, Uppsala SE-751 85, Sweden.
Collagen type VI (COL6) is an important component of the extracellular matrix (EM) and may have a major role in lung development and disease. Studies on COL6 expression during lung development are mainly based on animal models. The aim of the study was to define COL6 expression pattern in lung parenchyma in infants with different lung maturational stages.
View Article and Find Full Text PDFPlatelet ultrastructural changes stored at room temperature versus cold storage observed by electron microscopy and structured illumination microscopy.
Exp Hematol
January 2025
Department of Transfusion Medicine, Shaanxi Provincial Peoples Hospital, Xi'an, China. Electronic address:
Our study seeks to provide a theoretical foundation for the clinical use of cold-stored platelets (CSPs) by interpreting ultrastructural images and quantitatively analyzing structural changes. CSPs, room temperature-stored platelets (RTPs), and delayed CSPs (delayed-CSPs) were continuously observed using scanning electron microscopy and transmission electron microscopy at eight time points. Super-resolution fluorescence microscopy was employed to observe changes in platelet microtubules and mitochondrial structure and function, whereas platelet counts, metabolism, and relevant functional indicators were measured concurrently.
View Article and Find Full Text PDFEvaluating the influence on osteocyte mechanobiology within the lacunar-canalicular system for varying lacunar equancy and perilacunar elasticity: A multiscale fluid-structure interaction analysis.
J Mech Behav Biomed Mater
December 2024
Department of Aerospace Engineering and Applied Mechanics, Indian Institute of Engineering Science and Technology, Shibpur, Howrah, India. Electronic address:
Article Synopsis
- The study investigates how the shape and properties of osteocytes (bone cells) change in different health conditions and how this impacts their mechanics within bone structures, specifically the lacunar-canalicular system (LCS).
- A detailed model was created to analyze the effects of fluid dynamics and mechanics on osteocytes when various parameters of their environment, like lacunar equancy (shape) and perilacunar elasticity, were modified.
- Results indicated that healthier conditions (younger bone) show increased mechanical stimulation in osteocytes with certain structural changes, while variations in fluid flow and stress significantly affect their responses based on the elasticity of surrounding matrix and regions.
HMGA2-positive salivary gland neoplasms with prominent trabecular/canalicular morphology: a focus on carcinomas arising within this phenotype.
Histopathology
February 2025
Robert J. Tomsich Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA.
Aims: Pleomorphic adenoma (PA) with a prominent trabecular/canalicular morphology has consistent HMGA2 protein expression, and association with HMGA2 fusions. We report our experience with this subtype, with emphasis on the carcinomas that can arise in this context.
Methods And Results: A retro- and prospective review (2013-2024) of major salivary gland tumours with prominent trabecular/canalicular morphology was performed.
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