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Mechanistic insights into the competitive inhibition of enzyme-mimetic activity of gold nanoparticles for dual mode colorimetric and fluorescence detection of biothiols.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Division of Molecular Medicine, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram 695012, India. Electronic address:
In this work, the interaction behaviour of gold nanoparticles (AuNPs) with o-phenylenediamine (OPD) was studied to ascertain the nanozyme-substrate interaction. The UV-Vis absorption, high-resolution transmission electron microscopy and zeta potential analysis revealed that the electron-rich nitrogen atoms in OPD showed a stronger affinity toward electron-deficient surface, indicating a stronger interaction between nanozyme and substrate molecules. Subsequently, under optimum conditions, AuNPs are used as nanozyme to catalyze the oxidation of OPD in the presence of HO.
View Article and Find Full Text PDFaqueous leaf extract modulates metformin pharmacokinetics, inhibits CYP3A4 and CYP2C9 enzymes in streptozotocin-induced diabetic rats.
J Complement Integr Med
December 2024
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia.
Objectives: Del. leaves are used in traditional Southeast Asia and Africa medicinal practices. Metformin is used for diabetes management.
View Article and Find Full Text PDFNovel enhanced detection and resolution of a nonfluorescent mixture in plasma at nanogram levels using sustainable fluorescent carbon dots and advanced chemometric models.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Pharmaceutical Chemistry Dept., Faculty of Pharmacy, Ahram Canadian University, Cairo, Egypt.
For the first time, advanced chemometric models were utilized to determine florescence induced by carbon dots. In an endeavor to regulate anthelmintic drug usage by facilitating the determination of veterinary formulations in animals' biological fluids, a novel fluorometric-assisted chemometric method has been developed for detecting two nonfluorescent drugs, Ivermectin (IVR) and Clorsulon (CLR). The method relies on the linear quenching effect of the drugs on the fluorescence intensity of carbon dots (CDs) synthesized from natural sources.
View Article and Find Full Text PDFA simple chromone-derived fluorescent "Turn-on" probe for accurate detection of Al Ions: Applications in food Analysis, test strips and bioimaging.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Henan Institute of Advanced Technology, and Pingyuan Laboratory, Zhengzhou University, Zhengzhou 450001, China. Electronic address:
To address the toxicity concerns of aluminum ions (Al) due to their widespread environmental presence, a novel chromone-derived fluorescent probe, (E)-N'-((4-oxo-4H-chromen-3-yl)methylene)benzohydrazide (NMA), was developed for dual-mode detection combining colorimetric and fluorometric channels. Upon chelation with Al in a 1:1 stoichiometric ratio, NMA exhibited a significant fluorescence enhancement at 510 nm, accompanied by a rapid and visible color change due to the chelation-enhanced fluorescence (CHEF) effect, achieving an exceptional detection limit of 9 nM-well below the World Health Organization's recommended threshold. The reversible binding of NMA, demonstrated through sequential addition of Al and EDTA, enabled the construction of an INHIBIT molecular logic gate, broadening its potential for smart sensing applications.
View Article and Find Full Text PDFEffects of piperine-haloperidol mixture on ketamine induced schizophrenia rats and metabolism-mediated inhibitory potency: in-vivo and in-vitro evaluation.
3 Biotech
December 2024
Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRMIST, Kattankulathur, Chengalpattu, Tamil Nadu 603 203 India.
Haloperidol, a conventional antipsychotic, was mixed with piperine in a ketamine-induced schizophrenia rat model to evaluate the interaction potential of this mixture through in-vitro and in-vivo analyses. Piperine, known for its CYP450 enzyme inhibitory effects, enhances the bioavailability of various drugs. Initial in-vitro assays using a high-throughput fluorometric method showed that the haloperidol-piperine mixture inhibited CYP3A4 and CYP2D6 enzymes, comparable to positive controls.
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