Background: Previous studies have reported that reduced visual acuity is associated with functional dependence in older persons. The purpose of this study was to determine whether components of vision impairment besides reduced acuity contribute to reduced functional independence.
Methods: Community dwelling adults aged 65 years and older were administered a battery of vision tests including distance acuity, letter contrast sensitivity, disability glare, and stereoacuity. A physical function questionnaire assessed self-reported difficulty with activities of daily living (ADL's), Instrumental activities of daily living (IADL's), and mobility activities. A visual function questionnaire assessed self-reported difficulty with a wide variety of everyday visual activities.
Results: Multiple logistic regression analysis showed that reduced acuity and reduced contrast sensitivity were independently associated with an overall vision disability score. Acuity was associated with difficulty in tasks requiring good resolution and adaption to changing light conditions, whereas contrast sensitivity was associated with difficulty in tasks requiring distance judgments, night driving, and mobility. Glare and stereoacuity were not associated with self-reported disability.
Conclusions: Reduced acuity and contrast sensitivity are significant risk factors for self-reported disability.
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http://dx.doi.org/10.1097/00006324-199412000-00005 | DOI Listing |
Mol Ther
January 2025
Faculty of Biology, Medicine & Health, University of Manchester, Manchester, M13 9PT, UK. Electronic address:
Optogenetic therapy is a promising vision restoration method where light sensitive opsins are introduced to the surviving inner retina following photoreceptor degeneration. The cell type targeted for opsin expression will likely influence the quality of restored vision. However, a like-for-like pre-clinical comparison of visual responses evoked following equivalent opsin expression in the two major targets, ON bipolar (ON BCs) or retinal ganglion cells (RGCs), is absent.
View Article and Find Full Text PDFMagn Reson Med
January 2025
Université Grenoble Alpes, INSERM, U1216, Grenoble Institute Neurosciences, GIN, Grenoble, France.
Purpose: This study proposes a novel, contrast-free Magnetic Resonance Fingerprinting (MRF) method using balanced Steady-State Free Precession (bSSFP) sequences for the quantification of cerebral blood volume (CBV), vessel radius (R), and relaxometry parameters (T , T , T *) in the brain.
Methods: The technique leverages the sensitivity of bSSFP sequences to intra-voxel frequency distributions in both transient and steady-state regimes. A dictionary-matching process is employed, using simulations of realistic mouse microvascular networks to generate the MRF dictionary.
Urologia
January 2025
Department of Urology and Renal Transplantation, Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow, Lucknow, Uttar Pradesh, India.
Introduction: Pseudotumors are benign lesions which may mimic like a malignant tumor on conventional imaging. They are formed in kidneys which are scarred and deformed by chronic pyelonephritis, glomerulonephritis, trauma or infarction. There is a diagnostic dilemma in most of the cases as to differentiate RCC and pseudotumors.
View Article and Find Full Text PDFBMC Ophthalmol
January 2025
Department of Optometry, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: The psychometric properties of the Convergence Insufficiency Symptom Survey (CISS) have been previously determined across the younger adult population. This study investigated the psychometric properties of the CISS in presbyopic adults via classical and Rasch analysis.
Methods: A total of 100 presbyopic individuals (40-60 years) were selected with far and near acuity of 20/20 with their habitual spectacles; 50 had convergence insufficiency and 50 had normal binocular vision.
Eur J Pediatr
January 2025
Hospital de Clinicas de Porto Alegre, Rua Silva Jardim 1155 # 701, Porto Alegre, RS, 90450-071, Brazil.
Unlabelled: To evaluate the accuracy of the lung ultrasound score (LUS) in predicting ventilatory weaning failure during neonatal hospitalization in the NICU and to identify factors associated with weaning failure, including corrected gestational age (CGA). This prospective, longitudinal, pragmatic and observational cohort study included neonates on mechanical ventilation for at least 48 h. The primary outcome was the accuracy of lung ultrasound in predicting 3-day weaning failure, with the ROC curve used to determine the best LUS cutoff (sensitivity and specificity).
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