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- The study examines how chronic exposure to digoxin affects locomotor activity and brain chemistry in zebrafish.
- Zebrafish were housed in groups and exposed to 2 μM of digoxin for a week, resulting in increased hyperactivity and decreased anxiety in a novel environment test.
- The findings reveal significant changes in brain monoamine levels, indicating that cardiotonic steroids like digoxin can influence neurotransmission, which might have implications for neuropsychiatric conditions.
Chronic Constrictive Pericarditis in Northeast India: A 10-Year Single-Center Study of Demographic and Clinical Profiles.
Cureus
November 2024
Department of Pathology, All India Institute of Medical Sciences, Guwahati, Guwahati, IND.
Article Synopsis
- Chronic constrictive pericarditis (CCP) is a disease marked by the thickening of the pericardium, leading to heart function issues, with a focus on patient demographics and clinical profiles in Northeast India over a decade.
- The study analyzed 42 CCP patients between 2011 and 2020, highlighting a high prevalence in younger individuals and a significant history of tuberculosis among participants.
- Symptoms included dyspnea and physical exam findings such as edema and hepatomegaly; imaging revealed notable heart structural changes, emphasizing the need for better diagnosis and management in the region.
Pediatric Chronic Heart Failure: Age-Specific Considerations of Medical Therapy.
Physiol Res
November 2024
Children's Heart Centre, Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic.
Chronic heart failure (CHF) is a rare entity in children but carries a burden of high mortality and morbidity. Medical treatment of pediatric CHF is largely based on guidelines for the adult population. In contrast to adults, evidence for the efficacy of medications in treating CHF in children is sparse.
View Article and Find Full Text PDFATRIAL FIBRILLATION IN WEST AFRICA: LESSONS GLEANED FROM THE IBADAN AF PROJECT.
West Afr J Med
November 2024
Cardiology Unit, Department of Medicine, University of Ibadan/University College Hospital, Ibadan, Nigeria Email:
Introduction/background: There is still little data on clinical profile and atrial fibrillation (AF) characteristics in West Africa. Traditionally the risk factor for chronic AF in the sub-region is chronic rheumatic heart disease. However, with the rapid demographic and epidemiologic transition in the sub-region, the risk factors, clinical profile, and complications of AF appear to be changing.
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