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Influence of Flagella on Enteritidis Sedimentation, Biofilm Formation, Disinfectant Resistance, and Interspecies Interactions.
Foodborne Pathog Dis
November 2024
College of Tourism and Cuisine Science, Yangzhou University, Yangzhou, China.
Flagella are essential for bacterial motility and biofilm formation by aiding bacterial attachment to surfaces. However, the impact of flagella on bacterial behavior, particularly biofilm formation, remains unclear. This study constructed two flagellar mutation strains of Enteritidis (SE), namely, SE-Δ and SE-Δ, and confirmed the loss of flagellar structures and motility in these strains.
View Article and Find Full Text PDFCypher/ZASP drives cardiomyocyte maturation via actin-mediated MRTFA-SRF signalling.
Theranostics
August 2024
Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
- Cardiomyocytes (CMs) experience significant structural and functional changes as they mature after birth, but the exact regulatory mechanisms are not fully understood; Cypher/ZASP is important for maintaining Z-disc stability and its deletion or mutation is linked to dilated cardiomyopathy (DCM).* -
- Research using various techniques revealed that Cypher plays a critical role in CM maturation, with RNA sequencing identifying serum response factor (SRF) as a key regulatory transcription factor affected by the absence of Cypher.* -
- The lack of Cypher disrupts proper sarcomere function and mitochondrial structure, leading to impaired cardiac function, but restoring SRF during the postnatal period can reverse these defects and improve overall cardiac performance
Evolution of a Restriction Factor by Domestication of a Yeast Retrotransposon.
Mol Biol Evol
March 2024
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Transposable elements drive genome evolution in all branches of life. Transposable element insertions are often deleterious to their hosts and necessitate evolution of control mechanisms to limit their spread. The long terminal repeat retrotransposon Ty1 prime (Ty1'), a subfamily of the Ty1 family, is present in many Saccharomyces cerevisiae strains, but little is known about what controls its copy number.
View Article and Find Full Text PDFGlutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization.
J Mol Cell Cardiol
March 2024
Department of Biological Sciences, University of Massachusetts Lowell, One University Ave, Lowell, MA 01854, United States of America. Electronic address:
The cardiac thin filament proteins troponin and tropomyosin control actomyosin formation and thus cardiac contractility. Calcium binding to troponin changes tropomyosin position along the thin filament, allowing myosin head binding to actin required for heart muscle contraction. The thin filament regulatory proteins are hot spots for genetic mutations causing heart muscle dysfunction.
View Article and Find Full Text PDFThe role of microtubule-associated protein tau in netrin-1 attractive signaling.
J Cell Sci
January 2024
Department of Biological Sciences, University of Toledo, M. S. 601, 2801 W. Bancroft St., Toledo, OH 43606, USA.
Direct binding of netrin receptors with dynamic microtubules (MTs) in the neuronal growth cone plays an important role in netrin-mediated axon guidance. However, how netrin-1 (NTN1) regulates MT dynamics in axon turning remains a major unanswered question. Here, we show that the coupling of netrin-1 receptor DCC with tau (MAPT)-regulated MTs is involved in netrin-1-promoted axon attraction.
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