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New routes for spermine biosynthesis.
J Biol Chem
March 2025
Department of Biochemistry, UT Southwestern Medical Center, Dallas, Texas, USA. Electronic address:
The polyamine spermine is a flexible linear teraamine found in bacteria and eukaryotes, and in all known cases is synthesized from triamine spermidine by addition of an aminopropyl group acquired from decarboxylated S-adenosylmethionine (dcAdoMet). We have now identified in bacteria a second biosynthetic route for spermine based on the formation of carboxyspermine from spermidine, dependent on aspartate β-semialdehyde (ASA). This route also produces thermospermine from spermidine via carboxythermospermine.
View Article and Find Full Text PDFInitial Real-World Pilot of the MedMorph Reference Architecture: Hepatitis C Surveillance and Research.
Appl Clin Inform
March 2025
Centers for Disease Control and Prevention, Atlanta, Georgia, United States.
Objectives: This study aimed to demonstrate real-world use of the Making Electronic Data More Available for Research and Public Health (MedMorph) Reference Architecture (RA) for automated exchange of hepatitis C-related data for public health surveillance and research using Fast Healthcare Interoperability Resources (FHIR).
Methods: Pilot participants included a public health authority (PHA), research organization (RO), clinical sites, and electronic health record (EHR) vendors. The RA was tested for hepatitis C public health surveillance and research data exchange.
Polyphosphatases have a polyphosphate-independent influence on the virulence of .
Infect Immun
March 2025
Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
an invasive basidiomycete fungal pathogen, causes one of the most prevalent, life-threatening diseases in immunocompromised individuals and accounts for ~19% of AIDS-associated deaths. Therefore, understanding the pathogenesis of and its interactions with the host immune system is critical for developing therapeutics against cryptococcosis. Previous studies demonstrated that cells lacking polyphosphate (polyP), an immunomodulatory polyanionic storage molecule, display altered cell surface architecture but unimpaired virulence in a murine model of cryptococcosis.
View Article and Find Full Text PDFOrganobase-catalyzed tandem green hemisynthesis of novel 1,4-naphthoquinone-chromene derivative from (Cosson & Durieu) essential oil; antimicrobial activity and exploration against psoriasis-associated receptors.
Nat Prod Res
March 2025
Laboratoire de Catalyse et Synthèse en Chimie Organique, Faculté des Sciences, Université de Tlemcen, Tlemcen, Algérie.
Chemical and biological properties of a novel 1,4-naphtoquinone-chromene derivative synthesised from perillaldehyde, major compound of essential oil were evaluated. The obtained product was efficiently prepared through a tandem hemisynthesis reaction under environmentally friendly conditions (solvent-free, moderate temperature) Knoevenagel condensation and Michael addition reactions, using 4-pyrolidinopyridine organobase as a catalyst. The structure of newly synthesised product ( was characterised using FTIR,H,C and 2D NMR spectroscopy.
View Article and Find Full Text PDFDesign and Application of Fluorescent Probes Based on Flavonoid Dyes for Cysteine Detection.
J Fluoresc
March 2025
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi, 710127, China.
As an important reactive sulfur species, cysteine plays a crucial role in maintaining the body's redox homeostasis and regulating protein function. Its content in organisms can serve as signaling molecules to directly or indirectly detect certain diseases. Therefore, based on the Michael addition mechanism, five flavonoid fluorescent probes HFL1-5 were designed and synthesized to detect cysteine.
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