In order to improve the preoperative diagnosis of superficial skin tumors in the head and neck, 32 patients with 42 basal cell carcinomas, squamous cell carcinomas and malignant melanomas were investigated using different imaging techniques. All patients were examined preoperatively with high-frequency ultrasound (HFU), computed tomography (CT) and magnetic resonance imaging (MRI). New high-frequency ultrasonic scanners (15- and 20-MHz) having an axial resolution of 50-90 microns permit visualization of dermal and cartilaginous structures with an anatomical accuracy to a range of 15 mm in tissue. Exact measurement of the skin tumors and their relation to adjacent structures was feasible. Histologically different tumors could be discriminated by their echo-structure in 80% of the cases. CT and MRI provided additional information when the tumor extension perpendicular to the skin exceeded 15 mm. If tumor extension was less than 15 mm, CT and MRI were inferior to high-frequency ultrasound in the diagnosis of superficial skin tumors and did not provide any additional information. The experience reported has shown that high-frequency ultrasound is a valuable tool for preoperative evaluation of superficial skin tumors in terms of tumor extension and possible invasion of functionally and esthetically important adjacent structures. This knowledge can support preoperative planning of possible resections as well as reconstruction and may help to obtain an appropriate informed consent.
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Mol Cancer Res
January 2025
Weill Cornell Medicine, New York, NY, United States.
Kaposi Sarcoma (KS) is a frequently aggressive malignancy caused by Kaposi sarcoma herpesvirus (KSHV/HHV-8). People with immunodeficiencies, including HIV, are at increased risk for developing KS, but our understanding of the contributions of the cellular genome to KS pathogenesis remains limited. To determine if there are cellular genetic alterations in KS that might provide biological or therapeutic insights, we performed whole exome sequencing on 78 KS tumors and matched normal control skin from 59 adults with KS (46 with HIV-associated KS and 13 with HIV-negative KS) receiving treatment at the Uganda Cancer Institute in Kampala, Uganda.
View Article and Find Full Text PDFJMIR Cancer
January 2025
Department of Medical Oncology, Antoni van Leeuwenhoek, Amsterdam, Netherlands.
Background: Patients with melanoma receiving immunotherapy with immune-checkpoint inhibitors often experience immune-related adverse events, cancer-related fatigue, and emotional distress, affecting health-related quality of life (HRQoL) and clinical outcome to immunotherapy. eHealth tools can aid patients with cancer in addressing issues, such as adverse events and psychosocial well-being, from various perspectives.
Objective: This study aimed to explore the effect of the Cancer Patients Better Life Experience (CAPABLE) system, accessed through a mobile app, on HRQoL compared with a matched historical control group receiving standard care.
J Exp Clin Cancer Res
January 2025
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Recent advances in oncology research have highlighted the promising synergy between low-dose radiation therapy (LDRT) and immunotherapies, with growing evidence highlighting the unique benefits of the combination. LDRT has emerged as a potent tool for stimulating the immune system, triggering systemic antitumor effects by remodeling the tumor microenvironment. Notably, LDRT demonstrates remarkable efficacy even in challenging metastatic sites such as the liver (uveal) and brain (cutaneous), particularly in advanced melanoma stages.
View Article and Find Full Text PDFBMC Palliat Care
January 2025
Palliative Care Unit, National Cancer Institute, Rio de Janeiro, Brazil.
Objective: To compare the sociodemographic and clinical profiles of patients with advanced cancer admitted to a tertiary palliative care unit before and during the COVID-19 pandemic.
Methods: This is an analysis of data from patients receiving care before (10/21/2019 to 03/16/2020) and during (09/23/2020 to 08/26/2021) the COVID-19 pandemic. Sociodemographic and clinical data were evaluated.
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