In one case of diabetes, normal glucose contents and volumes of the urine and high diabetic values alternate with each other. This periodicity may be of short duration (a couple of days), but long-lasting normal state can also occur. This state of aperiodicity may last almost a month. In such "smoothening" of hormone-regulation, some modulator substances may play a role.
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Cureus
October 2020
Health Care Administration, University of Cincinnati Health, Cincinnati, USA.
Optimal blood glucose control helps reduce the development of the complications of type II diabetes mellitus (T2DM). T2DM patients usually are at increased risk of cardiovascular (CV) events and mortality. Therapies and strategies to treat diabetes and its related CV outcomes still need more investigation to find the best management options for this population.
View Article and Find Full Text PDFActa Physiol Hung
April 1995
Pharmaceutical Works Chinoin, Department of Pharmacology, Budapest, Hungary.
In one case of diabetes, normal glucose contents and volumes of the urine and high diabetic values alternate with each other. This periodicity may be of short duration (a couple of days), but long-lasting normal state can also occur. This state of aperiodicity may last almost a month.
View Article and Find Full Text PDFGuinea pigs injected with streptozotocin were significantly hyperglycemic on day 1 after injection but only mildly so on day 14. However, serum insulin levels were significantly depressed on day 14; at this time the animals had lost 25% of their initial body weights and were severely glycosuric. The volume fraction of immunostainable B cells in the pancreas was reduced to one third of control values by day 1 after injection and remained at this level by day 14.
View Article and Find Full Text PDFAnn Acad Med Singap
April 1985
The degree of control of 132 diabetic patients was assessed using historical data, urine glucose and blood glucose measurements. These were then related to HbA1, taken as the final arbiter of glycaemic control. Symptoms of hyperglycaemia and glycosuria were found to be not sensitive or specific indices of control, though symptomatic glycosuric patients tended to have higher HbA1.
View Article and Find Full Text PDFJ Pharmacol Exp Ther
April 1985
To determine the effect of diabetes mellitus on gentamicin nephrotoxicity we treated male F344 rats with streptozotocin 22 mg/kg (DM rats). DM rats were compared to controls (C) and nondiabetic rats ingesting the osmotic diuretic isosorbide administered to simulate glycosuric diuresis (C/I). Base-line C/I renal function and histology did not differ from C.
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