Platelet-derived growth factor (PDGF) is a heterodimeric glycoprotein consisting of A and B chains. A functional promoter had been identified in the 5' flanking region of the human PDGF-A chain gene. We found that the PDGF-A chain promoter region possesses the potential for bidirectional activity. This bidirectional promoter activity is influenced by the 5'-untranslated region (5'-UTR) and serum concentration. The 5'-UTR may regulate expression of the PDGF-A chain by transcription in the opposite direction.
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Niosome-encapsulated auraptene reduced the mRNA expression of and genes in human retina-derived RPE cell line.
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Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, Jacksonville, FL, USA. Electronic address:
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View Article and Find Full Text PDFevaluation of the antitumor activity of axitinib in canine mammary gland tumor cell lines.
J Vet Sci
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Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
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Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China. Electronic address:
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