Oxygen consumption following pediatric cardiac surgery.

J Cardiothorac Vasc Anesth

Department of Anesthesiology, University Children's Hospital, Helsinki, Finland.

Published: December 1994

AI Article Synopsis

Article Abstract

Metabolic responses during recovery from cardiac operations for various congenital heart defects were studied in 30 mechanically ventilated pediatric patients in two groups: infants 1 year or less (group I) and children more than 1 year old (group II). Oxygen consumption (VO2) and carbon dioxide production (VCO2) were measured using a pediatric metabolic monitor intermittently after induction of anesthesia, after skin closure, 2 to 4 hours postoperatively, and on the first postoperative morning in the pediatric intensive care unit. Energy expenditure and respiratory quotient were determined from respiratory gas measurements. Rectal and skin temperatures and hemodynamic variables were recorded at the same time. VO2 increased during rewarming 2 to 4 hours after the operation by 12 +/- 15% in group I and by 24 +/- 19% in group II, while rectal temperature increased by 2.0 +/- 1.2 degrees C and 1.8 +/- 1.4 degrees C, respectively. No further increase in VO2 occurred until the first postoperative morning. A hypermetabolic response was not seen in all cases despite marked thermal changes. High-dose fentanyl anesthesia partly explains the low responses. On the other hand, low cardiac output may also compromise oxygen supply. Sixty-three percent of infants were treated for cardiac failure before surgery and 75% needed inotropic support immediately after the operation. Low central venous oxyhemoglobin saturation values (ScvO2 < 60%) were observed during rewarming, indicating an increase in oxygen extraction secondary to an increased oxygen demand in the brain during recovery from anesthesia, and a low cardiac output or delayed restoration of cerebral blood flow after CPB and deep hypothermia.

Download full-text PDF

Source
http://dx.doi.org/10.1016/1053-0770(94)90195-3DOI Listing

Publication Analysis

Top Keywords

oxygen consumption
8
year group
8
postoperative morning
8
+/- degrees
8
low cardiac
8
cardiac output
8
oxygen
5
cardiac
5
pediatric
4
consumption pediatric
4

Similar Publications

Electrochemical nitrate reduction (NORR) to ammonia presents a promising alternative strategy to the traditional Haber-Bosch process. However, the competitive hydrogen evolution reaction (HER) reduces the Faradaic efficiency toward ammonia, while the oxygen evolution reaction (OER) increases the energy consumption. This study designs IrCu alloy nanoparticles as a bifunctional catalyst to achieve efficient NORR and OER while suppressing the unwanted HER.

View Article and Find Full Text PDF

The maximal oxygen uptake (V̇O) is typically higher in endurance-trained adolescents than in non-endurance-trained peers. However, the specific mechanisms contributing to this remain unclear, as well as the impact of training during this developmental stage. This study aims to compare V̇O and cardiovascular functions between 12-year-old endurance athletes and non-endurance-trained over a 14-month period.

View Article and Find Full Text PDF

Parthenolide improves sepsis-induced coagulopathy by inhibiting mitochondrial-mediated apoptosis in vascular endothelial cells through BRD4/BCL-xL pathway.

J Transl Med

January 2025

Department of Anesthesiology, Daping Hospital, Army Medical University, No.10, Changjiang Road, Yuzhong District, Chongqing, 400042, China.

Background: Sepsis is a systemic inflammatory syndrome that can cause coagulation abnormalities, leading to damage in multiple organs. Vascular endothelial cells (VECs) are crucial in the development of sepsis-induced coagulopathy (SIC). The role of Parthenolide (PTL) in regulating SIC by protecting VECs remains unclear.

View Article and Find Full Text PDF

Introduction And Objectives: Cardiopulmonary exercise testing (CPET) is the gold standard for quantifying aerobic functional capacity, yet it is costly and not widely available. The CLINIMEX Aerobic Fitness Questionnaire (C-AFQ) may be a practical alternative as it estimates oxygen consumption at peak exercise (VO peak) based on patients' responses to a list of activities with known energy requirements. However, its applicability in cardiac patients is unclear and has not yet been studied.

View Article and Find Full Text PDF

Ectotherms are considered more susceptible to global warming. Variations in ambient temperature are especially alarming as the majority of animals are ectothermic, with temperature seen as a crucial determinant of their ecology, biogeography, behaviour, and physiology. Ectotherms, which depend on external ambient temperatures to regulate their body temperature, exhibit various physiological and metabolic responses to variations in temperature.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!