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To assess the biochemical, mechanical and structural characteristics of retained dentin after applying three novel bromelain-contained chemomechanical caries removal (CMCR) formulations in comparison to the conventional excavation methods (hand and rotary) and a commercial papain-contained gel (Brix 3000). Seventy-two extracted permanent molars with natural occlusal carious lesions (score > 4 following the International Caries Detection and Assessment System (ICDAS-II)) were randomly allocated into six groups (n = 12) according to the excavation methods: hand excavation, rotary excavation, Brix 3000, bromelain-contained gel (F1), bromelain-chloramine-T (F2), and bromelain-chlorhexidine gel (F3). The superficial and deeper layers of residual dentin were examined by Raman microspectroscopy and Vickers microhardness, while the surface morphology was assessed by the scanning electron microscope (SEM).

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Article Synopsis
  • The study explores how traditional Chinese medicine, specifically Shengji Ointment, can effectively treat diabetic foot ulcers in the elderly, aiming to develop a predictive model for healing these complex wounds.
  • Involving 180 elderly patients with severe diabetic foot ulcers, the research analyzes various factors—including treatment type, demographic data, and health indicators—to determine their impact on granulation tissue development, utilizing advanced statistical methods like Lasso and Cox regression.
  • Key findings indicate that a combination of Shengji Ointment and bromelain enhances healing, while factors like ulcer location, kidney function, obesity, and anemia serve as significant risk predictors, with the predictive model showing considerable accuracy in outcomes.
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Background: Bromelain is a complex mixture of protease enzyme extract from the fruit or stem of the pineapple plant and it has a history of folk medicine use. It is known to have a wide range of biological actions and it is most commonly used as an anti-inflammatory agent, though scientists have also discovered its potential as an anticancer and antimicrobial agent, it has been reported to have positive effects on the respiratory, digestive, circulatory systems and potentially on the immune system.

Objective: This study was designed to investigate the antidepressant potential of Bromelain in the chronic unpredictable stress (CUS) model of depression.

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Aluminum (Al) is an important factor in the environment as it is used in agriculture and several industries leading to hazardous effects via oxidative stress. Bromelain is a cheap extract from the byproduct waste of stem. It has been used in several biological and therapeutic applications.

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Physicochemical and in vitro protein digestibility of alginate/calcium (AC) restructured pork steak hydrolyzed with bromelain with addition of LA gellan, LM pectin and κ-carrageenan at various concentrations (0.5, 1.0, 1.

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