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Idebenone protects hepatic microsomes against oxygen radical-mediated damage in organ preservation solutions.
Transplantation
September 1995
Abteilung Klinische Chemie, Georg-August-Universität Göttingen, Germany.
The ability of the benzoquinone coenzyme Q-10 or its derivative QSA-10 (idebenone) to protect against lipid peroxidation and protein damage mediated by the pro-oxidative system NADPH/ADP/Fe3+ was tested in a rat liver microsomal model incubated in University of Wisconsin (UW) or histidine-tryptophan-ketoglutarate (HTK) solutions. Lipid peroxidation, as followed by direct determination of lipid hydroperoxides and by monitoring of malondialdehyde equivalents, was 1.8-fold enhanced in HTK and 3-fold attenuated in UW compared with HEPES buffer.
View Article and Find Full Text PDFQSA 10 (idebenone) or probucol supplementation of organ preservation solutions prevents oxygen radical-mediated injury of hepatic microsomes.
Transplant Proc
February 1995
Department of Clinical Chemistry, Georg-August-Universität, Göttingen, Germany.
[Synthesis and biochemical actions of idebenone and related compounds. Ubiquinone and related compounds, XL].
Naturwissenschaften
May 1989
Nangocho 2-29, Nishinomiya-shi/Japan.
Syntheses of some metabolites of ubiquinone and of related compounds are described. Idebenone (QSA-10), a methyl-dimethoxy-benzoquinone bearing an omega-hydroxydecyl side chain in 3-position, restored the oxidation of succinate and of NADH in ubiquinone-depleted mitochondrial preparations and showed a stabilizing effect on lysosomal membranes and an inhibitory effect on cAMP-phosphodiesterase. It inhibited lipid peroxidation in canine brain mitochondria and in microsomes from canine brain and rat liver.
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