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-Associated Paroxysmal Dystonia.
Tremor Other Hyperkinet Mov (N Y)
December 2024
Veracity Neuroscience LLC, Memphis, Tennessee, USA.
Background: mutations are associated with a diverse set of distinct neurological syndromes and intermediate phenotypes that may include extra-neural features. Overall, genotype-phenotype correlations are weak. There are no consensus treatments.
View Article and Find Full Text PDFYanghe decoction inhibits inflammation-induced lung metastasis of colorectal cancer.
J Ethnopharmacol
December 2024
School of Nursing, Yunnan University of Chinese Medicine, Kunming, 650500, China. Electronic address:
Ethnopharmacological Relevance: Positive deficiency and cancer toxicity are the main pathogenesis of colorectal cancer (CRC) lung metastasis. Yanghe decoction (YHD), a traditional Chinese medicine, has the effects of warming yang, tonifying blood, dispersing cold and clearing stagnation, adopting a treatment method that combines supporting the right and dispelling the wrong, which has remarkable efficacy in anti-tumor.Although, its precise mechanism of inhibiting the metastasis of colorectal cancer to the lung is still poorly understood.
View Article and Find Full Text PDFAn abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns.
Am J Hum Genet
November 2024
Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA; Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address:
Article Synopsis
- Research on abdominal obesity highlighted that the rs10494217 variant in the TBX15 gene is linked to adipocyte health and the heritability of obesity.
- The frequency of this variant shows a geographical trend, decreasing from north to south, particularly evident in the Finnish population, suggesting an adaptive response to colder climates.
- Individuals with the risk allele exhibit changes in gene expression related to thermogenesis and unhealthy fat cell growth, indicating the variant's possible role in promoting abdominal obesity.
Effects of priming duration and rhizosphere bacteria metabolite concentration on the germinability of cowpea, soybean, sesame, and okra seeds.
F1000Res
October 2024
Department of Biological Sciences, Afe Babalola University, Ado Ekiti, Ekiti, 360102, Nigeria.
Seed priming enhances germination and growth, which are important determinants of crop yield. This study was carried out to assess the effect of priming duration and metabolite concentration on the priming of five (5) different crops, using the metabolites of five (5) bacterial isolates. The crop seeds were treated in the cold-extracted metabolites of the five isolates at five (5) different priming durations (1, 2, 3, 4, and 5 h) and then in five metabolite concentrations (200, 400, 600, 800, and 1000 mg/L) of the five extracted metabolites at the optimal priming duration determined in the first experiment.
View Article and Find Full Text PDFPreventing social defeat stress-induced behavioural and neurochemical alterations by repeated treatment with a mix of , and standardized extracts.
Front Pharmacol
August 2024
Section of Pharmacology and Toxicology, Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.
Prolonged exposure to stress is a risk factor for the onset of several disorders. Modern life is burdened by a pervasive prevalence of stress, which represents a major societal challenge requiring new therapeutic strategies. In this context, botanical drug-based therapies can have a paramount importance.
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