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Effects of probiotics on clinical manifestations and inflammatory markers in HTLV-1-associated myelopathy/tropical spastic paraparesis: A triple blind randomized, placebo controlled trial.
Cytokine
January 2025
Department of Neurology, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Human T-lymphotropic virus type 1 (HTLV-1), leads to adult T-cell lymphoma/leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a minority of infected individuals. The virus promotes inflammation, a major factor in chronic disease progression. Probiotics' immune modulation and anti-inflammatory effects present a potential therapeutic intervention for HTLV-1-related conditions.
View Article and Find Full Text PDFSafety and efficacy of placental mesenchymal stromal cells-derived extracellular vesicles in knee osteoarthritis: a randomized, triple-blind, placebo-controlled clinical trial.
BMC Musculoskelet Disord
October 2024
Department of Biomedical and Electronics Engineering, School of Engineering, University of Bradford, Bradford, UK.
Article Synopsis
- - The study explored the safety and effectiveness of injecting placental mesenchymal stromal cells-derived extracellular vesicles into knees of patients with osteoarthritis, comparing it to a control group who received saline injections.
- - In a triple-blind, randomized clinical trial involving 62 knees (31 patients), various measures, including pain and function assessments, were taken before and after the treatment, but no significant improvements were found between the two groups after 2 and 6 months.
- - The conclusion highlighted that while the injection was safe with no severe reactions observed, it did not lead to any clinical improvement in knee osteoarthritis symptoms or MRI findings.
Mechanotransduction-Piloted Whole-Cell Vaccines for Spatiotemporal Modulation of Postoperative Antitumor Immunity.
ACS Nano
October 2024
State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China.
Article Synopsis
- * The challenges in developing these vaccines include improving adjuvant modification and understanding interactions within the postoperative environment.
- * This study introduces manganese oxide-immobilized tumor cell vaccines that can adjust stiffness to enhance immune response and demonstrated effectiveness in a mouse model, showing promise when combined with radiotherapy to reduce tumor recurrence.
Mitochondrial Sulfenated-Protein-Targeted Covalent Immobilization Boosting Efficient Copper(II) Depletion for Enhanced Cancer Treatment.
ACS Appl Mater Interfaces
October 2024
State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, P. R. China.
Article Synopsis
- Copper is crucial for cellular metabolism and managing oxidative stress, and targeting copper levels in mitochondria can help in diagnosing and treating triple-negative breast cancer (TNBC).
- Researchers have developed a new probe, d-IR-DPA, that can visualize and reduce copper levels in mitochondria, which aids in the quantitative detection of copper in tumors and promotes TNBC cell death.
- The use of this probe not only increases oxidative stress and damages mitochondrial membranes, but it also shifts cancer cells' energy production from oxidative phosphorylation to glycolysis, leading to reduced energy and significant tumor suppression in live mice.
Controllable Multi-Exciton Zero-Dimensional Antimony-Based Metal Halides for White-light Emission and β-Ray Detection.
Angew Chem Int Ed Engl
December 2024
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Chemistry and Biomedicine Innovation Center, Nanjing University, 210093, Nanjing, China.
Self-trapped exciton (STE) emission, typified by antimony (Sb), with broadband characteristics, represents the next generation of materials for solid-state lighting and radiation detection. However, little is known about the multiexciton behavior of the Sb emission center. Here, we proposed a general approach for designing antimony-centered multi-exciton emitting materials through self-assembly.
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