Twenty-six of 39 Syrian hamsters obtained by this laboratory from a pet supplier had enteritis and showed signs of "wet tail." An enteritis was reproduced in healthy hamsters by oral inoculation of homogenized ilea and jejuna from the diseased hamsters. The most characteristic pathologicfeatures were a variably enlarged distal jejunum and ileum and granulomatous lesions in the ileal subserosal wall. Histologic findings included a greatly hyperplastic jejunal and ileal mucosa that frequently contained submucosal accumulations of inflammatory cells. Often mucosal glands extended into these areas. The gross and histologic lesions produced were identical to those described in proliferative ileitis. Bacterial cultures from infected tissues consistently grew a slow lactose-fermenting Escherichia coli. Although diarrhea could be produced by oral inoculation of the organism, the typical morphologic lesions were not produced.
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ACS Nano
March 2025
School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, P.R. China.
Mucosal immunity plays a pivotal role in safeguarding against significant global infectious diseases caused by mucosal pathogens. The development of mucosal vaccines has been limited by the poor efficiency of antigen display and the risk of adjuvants. Here, we report an engineered yeast vaccine integrating a well-displayed antigen with an intrinsic adjuvant for the development of innate and adaptive immunity to the intestinal mucosa.
View Article and Find Full Text PDFJ Microbiol Biotechnol
March 2025
Department of Pharmacy, Medical Faculty, Universitas Brawijaya, Malang 65145, Indonesia.
has potential as a mucosal vaccine delivery system. can express antigens from bacteria or viruses, which are tightly controlled using nisin. Although -based vaccine shows great promise, no product is ready for human use.
View Article and Find Full Text PDFVaccine
March 2025
Bandim Health Project, Bissau, Guinea-Bissau; Research Unit OPEN, University of Southern Denmark/Odense University Hospital, Denmark; Centre for Global Health, Department of Clinical Research, University of Southern Denmark, Denmark.
Background: The COVID-19 pandemic response diverted health systems resources to COVID-19 activities. Modelling studies and estimates based on administrative data indicate that the number of un- and under-vaccinated children increased during the pandemic, especially in the world's poorest countries. We investigated vaccination coverage and timeliness among children born in rural Guinea-Bissau before and during the pandemic.
View Article and Find Full Text PDFAnimals (Basel)
March 2025
Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
Deciphering the gastrointestinal microbial response to oral SS DNA vaccines with different doses is helpful for identifying the mechanism for effective utilization of the vaccine for improving animal production. Here, we conduct a comparative study with different doses of vaccine (control: empty plasmid; low dose: 1 × 10 CFU vaccine; high dose: 1 × 10 CFU vaccine) using goat as a case to investigate the potential of somatostatin vaccination from the entire gastrointestinal microbiota perspective. Our results show that body weight gain and slaughter rate are greater in the L_SS group than in the C_SS group.
View Article and Find Full Text PDFEClinicalMedicine
March 2025
VA Boston Cooperative Studies Program, Boston, MA, USA.
Background: Novel strategies that account for population-level changes in dominant variants, immunity, testing practices and changes in individual risk profiles are needed to identify patients who remain at high risk of severe COVID-19. The aim of this study was to develop and prospectively validate a tool to predict absolute risk of severe COVID-19 incorporating dynamic parameters at the patient and population levels that could be used to inform clinical care.
Methods: A retrospective cohort of vaccinated US Veterans with SARS-CoV-2 from July 1, 2021, through August 25, 2023 was created.
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