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Recruitment of Corticotropin-Releasing Hormone (CRH) Neurons in Categorically Distinct Stress Reactions in the Mouse Brain.
Int J Mol Sci
July 2023
Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine Eötvös Loránd Research Network, 1083 Budapest, Hungary.
Corticotropin-releasing hormone (CRH) neurons in the paraventricular hypothalamic nucleus (PVH) are in the position to integrate stress-related information and initiate adaptive neuroendocrine-, autonomic-, metabolic- and behavioral responses. In addition to hypophyseotropic cells, CRH is widely expressed in the CNS, however its involvement in the organization of the stress response is not fully understood. In these experiments, we took advantage of recently available Crh-IRES-Cre;Ai9 mouse line to study the recruitment of hypothalamic and extrahypothalamic CRH neurons in categorically distinct, acute stress reactions.
View Article and Find Full Text PDFDynamics of cachexia-associated inflammatory changes in the brain accompanying intra-abdominal fibrosarcoma growth in Wistar rats.
J Neuroimmunol
March 2023
Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.
Accumulated data indicate that inflammation affecting brain structures participates in the development of cancer-related cachexia. However, the mechanisms responsible for the induction and progression of cancer-related neuroinflammation are still not fully understood. Therefore, we studied the time-course of neuroinflammation in selected brain structures and cachexia development in tumor-bearing rats.
View Article and Find Full Text PDFRole of Thyrotropin-Releasing Hormone in Regulating Fibroblast Growth Factor 21 in Mouse Pancreatic β Cells.
Thyroid
February 2023
Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.
Thyrotropin-releasing hormone (TRH) is primarily produced in the hypothalamus and regulates the thyrotropin secretion from the pituitary. TRH is distributed ubiquitously in the extrahypothalamic region, especially in pancreatic islets, while its physiological role remains nebulous. We have previously established a TRH-deficient mouse model, and showed impaired glucose tolerance and downregulated expression of fibroblast growth factor 21 (FGF21) in islets.
View Article and Find Full Text PDFExpression of Kisspeptin in the Adult Hamster Testis.
Dev Reprod
September 2022
Department of Biotechnology, Sangmyung University, Seoul 03016, Korea.
Article Synopsis
- Kisspeptins, derived from the KISS1 gene, are crucial regulators of GnRH neurons through their interaction with the GPR54 receptor, playing a key role in reproductive hormone signaling.
- The study investigates the presence of kisspeptin in Syrian hamster testes using RT-PCR and immunohistochemistry techniques, revealing detectable levels of kisspeptin in Leydig cells and some germ cells.
- These findings contribute to understanding the function of kisspeptin in hamster testes and its potential implications for reproductive physiology, particularly regarding the impact of photoperiod on gonadal regression.
Β-endorphin-immunoreactive perikarya appear to receive innervation from NPY-immunoreactive fiber varicosities in the human hypothalamus.
Brain Struct Funct
April 2022
Department of Epidemiology and Public Health and Anatomy and Neurobiology, University of Maryland Baltimore, 10 South Pine Street MSTF 977, Baltimore, MD, 21201, USA.
Morphological and pharmacological studies indicate that hypothalamic neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons communicate with each other in rats and regulate a variety of hypothalamic and extrahypothalamic functions. Indeed, electron microscopic studies revealed NPY-immunoreactive (NPI-IR) synapses on β-endorphin-IR neurons in the hypothalamus. However, no such connections have been reported in humans.
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